Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 5/20 | 0.33 |
| ▸ | MPO | P05164 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1-Naphthol SCHEMBL6832333 | 0.82 | CYP1A2 (0.47) | HRH1HTR2AMPOCYP1A2ALDH1A1 | |
| Histamine SCHEMBL28074178 | 0.81 | HRH1 (0.42) | HRH1HTR2AHTR1BCYP2A6TAAR1 | |
| Histamine SCHEMBL2279 | 0.81 | — | — | |
| Histamine SCHEMBL289072 | 0.81 | HRH4 (0.42) | HRH1SMN1; SMN2TSHRCYP2C9CYP2C19 | |
| Histamine SCHEMBL27340939 | 0.81 | — | — | |
| Histamine SCHEMBL5447892 | 0.81 | — | — | |
| Histamine SCHEMBL7444650 | 0.81 | HRH4 (0.42) | HRH1SMN1; SMN2TSHRCYP2C9CYP2C19 | |
| Histamine SCHEMBL1668636 | 0.81 | HRH4 (0.42) | HRH1SMN1; SMN2TSHRCYP2C9CYP2C19 | |
| Histamine SCHEMBL4760179 | 0.79 | — | — | |
| Histamine SCHEMBL21806473 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113013313-B | Flexible organic-inorganic composite thermoelectric film and preparation method and application thereof | 中国科学院上海硅酸盐研究所 | 2023-06-06 | — | — | CN | disclosed |
| US-20100028047-A1 | ELECTROPHOTOGRAPHIC PHOTORECEPTOR AND IMAGE FORMING APPARATUS | SHARP KABUSHIKI KAISHA (JP) | 2010-02-04 | — | — | US | disclosed |
| EP-0475644-A2 | A process for forming an electrophotographic imaging member | XEROX CORPORATION (US) | 1992-03-18 | — | — | EP | disclosed |