Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30772315 | 0.84 | HSP90AA1 (0.48) | FFAR1ALDH1A1HSP90AA1NTSR1CES2 | |
| SCHEMBL9189694 | 0.82 | HSP90AA1 (0.64) | PTGDR2FFAR1ALDH1A1KCNH2HSP90AA1 | |
| SCHEMBL31614587 | 0.82 | HSP90AA1 (0.64) | PTGDR2FFAR1ALDH1A1KCNH2HSP90AA1 | |
| SCHEMBL17493233 | 0.82 | PTGDR2 (0.50) | PTGDR2FFAR1ALDH1A1KCNH2HSP90AA1 | |
| SCHEMBL12430909 | 0.82 | PTGDR2 (0.46) | PTGDR2FFAR1ALDH1A1KCNH2HSP90AA1 | |
| SCHEMBL3863545 | 0.78 | ESR2 (0.49) | FFAR1ERCC5FEN1 | |
| SCHEMBL29162906 | 0.78 | FFAR1 (0.49) | PTGDR2FFAR1ALDH1A1CES2CES1 | |
| SCHEMBL852910 | 0.77 | PTGDR2 (0.46) | PTGDR2FFAR1KCNH2GRM5IKBKB | |
| SCHEMBL6577018 | 0.77 | TSHR (0.42) | FFAR1ALDH1A1CES2CES1ERCC5 | |
| SCHEMBL27343866 | 0.77 | KCNH2 (0.48) | PTGDR2FFAR1ALDH1A1KCNH2CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108424367-B | Method for preparing propiolic acid and derivatives thereof under mild condition | 中国科学院化学研究所 | 2020-08-18 | — | — | CN | disclosed |
| US-10745356-B2 | Compositions and methods for treating tuberculosis | THE BROAD INSTITUTE, INC. (US) | 2020-08-18 | — | — | US | disclosed |
| US-20190284140-A1 | COMPOSITIONS AND METHODS FOR TREATING TUBERCULOSIS | THE BROAD INSTITUTE, INC. | 2019-09-19 | — | — | US | disclosed |
| US-10329257-B2 | Compositions and methods for treating tuberculosis | THE BROAD INSTITUTE, INC. (US) | 2019-06-25 | — | — | US | disclosed |
| US-20180237394-A1 | COMPOSITIONS AND METHODS FOR TREATING TUBERCULOSIS | THE BROAD INSTITUTE, INC. | 2018-08-23 | — | — | US | disclosed |
| WO-2017027768-A1 | COMPOSITIONS AND METHODS FOR TREATING TUBERCULOSIS | THE BROAD INSTITUTE, INC. (US) | 2017-02-16 | — | — | WO | disclosed |
| WO-2010069754-A1 | CATIONIC RADIATION CURABLE COMPOSITIONS | AGFA GRAPHICS NV (BE) | 2010-06-24 | — | — | WO | disclosed |
| EP-0202490-B1 | METHOD FOR FORMING A POLYMER IMAGE AND IMAGE RECORDING MATERIAL THEREFOR | FUJI PHOTO FILM CO., LTD. (JP) | 1988-09-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10745356-B2 | Compositions and methods for treating tuberculosis | C5, IFNG, TERT | PTGDR2 2842/4885FFAR1 3074/4885ALDH1A1 1848/4885 |
| US-10329257-B2 | Compositions and methods for treating tuberculosis | C5, IFNG, TERT | PTGDR2 2842/4885FFAR1 3074/4885ALDH1A1 1848/4885 |
| US-20190284140-A1 | COMPOSITIONS AND METHODS FOR TREATING TUBERCULOSIS | C5, IFNG, TERT | PTGDR2 2842/4885FFAR1 3074/4885ALDH1A1 1848/4885 |
| US-20180237394-A1 | COMPOSITIONS AND METHODS FOR TREATING TUBERCULOSIS | C5, IFNG, TERT | PTGDR2 2842/4885FFAR1 3074/4885ALDH1A1 1848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.