Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.49 |
| ▸ | DRD3 | P35462 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.49 |
| ▸ | DRD1 | P21728 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | HTR2C | P28335 | 2/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.49 |
| ▸ | HRH1 | P35367 | 2/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.49 |
| ▸ | HTR2B | P41595 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | DRD4 | P21917 | 2/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3468502 | 0.82 | DRD2 (0.53) | DRD2CHRM1DRD3LMNACHRM2 | |
| SCHEMBL2369778 | 0.82 | DRD2 (0.62) | DRD2CHRM1DRD3LMNACHRM2 | |
| SCHEMBL3468597 | 0.82 | DRD2 (0.58) | DRD2CHRM1DRD3LMNACHRM2 | |
| SCHEMBL3229794 | 0.81 | DRD2 (0.55) | DRD2CHRM1DRD3LMNACHRM2 | |
| SCHEMBL3216890 | 0.79 | DRD2 (0.64) | DRD2CHRM1DRD3LMNACHRM2 | |
| SCHEMBL2159783 | 0.78 | DRD2 (0.54) | DRD2CHRM1DRD3LMNACHRM2 | |
| SCHEMBL2159818 | 0.78 | DRD2 (0.54) | DRD2CHRM1DRD3LMNACHRM2 | |
| SCHEMBL12395973 | 0.78 | DRD2 (0.54) | DRD2CHRM1DRD3LMNACHRM2 | |
| SCHEMBL2159819 | 0.78 | DRD2 (0.54) | DRD2CHRM1DRD3LMNACHRM2 | |
| SCHEMBL2159782 | 0.78 | DRD2 (0.54) | DRD2CHRM1DRD3LMNACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100016283-A1 | COMPOUNDS AND USES THEREOF - 150 | ASTRAZENECA AB (SE) | 2010-01-21 | — | — | US | disclosed |
| US-20100016283-A1 | COMPOUNDS AND USES THEREOF - 150 | ASTRAZENECA AB (SE) | 2010-01-21 | — | — | US | disclosed |
| WO-2009151392-A1 | NOVEL DERIVATIVES OF 11-PIPERAZIN-L-YLDIBENZO [B,F] [1,4] THIAZEPINE FOR TREATING AT LEAST ONE SYNDROME OR CONDITION ASSOCIATED WITH SCHIZOPHRENIA AND OTHER PSYCHOTIC DISORDERS | ASTRAZENECA AB (SE) | 2009-12-17 | — | — | WO | disclosed |
| WO-2008079839-A1 | COMPOUNDS AND USES THEREOF | ASTRAZENECA AB (SE) | 2008-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016283-A1 | COMPOUNDS AND USES THEREOF - 150 | MAPT, PSEN1, BACE1 | DRD2 239/4885CHRM1 625/4885DRD3 312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.