SCHEMBL3469293

SCHEMBL3469293

[C]1CSc2ccccc2N1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.44
MEN1 O00255 4/20 0.44
KMT2A Q03164 4/20 0.44
GAA P10253 3/20 0.44
ALOX12 P18054 2/20 0.38
MAPT P10636 2/20 0.38
NOX1 Q9Y5S8 2/20 0.38
CYP1A2 P05177 1/20 0.38
BCHE P06276 1/20 0.38
POLB P06746 1/20 0.38
CYP3A4 P08684 1/20 0.38
ADORA3 P0DMS8 1/20 0.38
ALOX15 P16050 1/20 0.38
MAOA P21397 1/20 0.38
CNR1 P21554 1/20 0.38
ACHE P22303 1/20 0.38
PTGS1 P23219 1/20 0.38
SLC6A2 P23975 1/20 0.38
HTR2C P28335 1/20 0.38
PTGS2 P35354 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11286921 1.00 ALDH1A1 (0.44) ALDH1A1MEN1KMT2AGAAALOX12
SCHEMBL6630478 0.68 ALDH1A1 (0.46) ALDH1A1MEN1KMT2AGAAALOX12
SCHEMBL582683 0.65
SCHEMBL19400 0.65
SCHEMBL23127930 0.65
SCHEMBL29452948 0.64
Hydrochloric Acid SCHEMBL29051623 0.64 ALDH1A1 (0.63) ALDH1A1MEN1KMT2AGAAALOX12
SCHEMBL2704673 0.64 GAA (0.41) ALDH1A1MEN1KMT2AGAAALOX12
Bromide SCHEMBL11683988 0.64 ALDH1A1 (0.57) ALDH1A1MEN1KMT2AGAAALOX12
SCHEMBL88911 0.62 GAA (0.96) ALDH1A1MEN1KMT2AGAAALOX12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2167196-A1 HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS Glaxo Group Limited (GB) 2010-03-31 EP disclosed
WO-2009000745-A1 HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS GLAXO GROUP LIMITED (GB) 2008-12-31 WO disclosed
EP-2001887-A1 PYRROLO-QUINOXALINONE DERIVATIVES AS ANTIBACTERIALS Glaxo Group Limited (GB) 2008-12-17 EP disclosed
EP-1963324-A1 HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR USE AS ANTIBACTERIALS GLAXO GROUP LIMITED (GB) 2008-09-03 EP disclosed
WO-2007115947-A1 PYRROLO-QUINOXALINONE DERIVATIVES AS ANTIBACTERIALS GLAXO GROUP LIMITED (GB) 2007-10-18 WO disclosed
WO-2007071936-A1 HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR USE AS ANTIBACTERIALS GLAXO GROUP LIMITED (GB) 2007-06-28 WO disclosed
EP-1605938-A4 ANTIBACTERIAL AGENTS GLAXO GROUP LTD (GB) 2006-11-22 EP disclosed
EP-1605938-A2 ANTIBACTERIAL AGENTS GLAXO GROUP LIMITED (GB) 2005-12-21 EP disclosed
WO-2004087145-A2 ANTIBACTERIAL AGENTS GLAXO GROUP LIMITED (GB) 2004-10-14 WO disclosed
US-4356302-A ANOREXIGENIC AGENTS G. D. SEARLE & CO. (US) 1982-10-26 US disclosed