Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EED | O75530 | 2/20 | 0.48 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.47 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | USP2 | O75604 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3469812 | 0.90 | ZAP70 (0.47) | EEDZAP70KARS1HSD17B10KDM4E | |
| SCHEMBL12409314 | 0.86 | MAPK1 (0.50) | EEDZAP70KARS1HSD17B10ALOX15 | |
| SCHEMBL3476687 | 0.85 | EED (0.51) | EEDZAP70KARS1FYNPIK3CG | |
| SCHEMBL3466394 | 0.83 | EED (0.51) | EEDZAP70KARS1TTK | |
| SCHEMBL3466367 | 0.83 | FYN (0.61) | EEDZAP70KARS1HTTFYN | |
| SCHEMBL3467556 | 0.82 | EED (0.51) | EEDHSD17B10KDM4ELMNAHTT | |
| SCHEMBL3467720 | 0.81 | FYN (0.62) | EEDZAP70KARS1HSD17B10ALOX15 | |
| SCHEMBL3470355 | 0.81 | CYP1A2 (0.53) | HSD17B10ALOX15TSHRFYNTP53 | |
| SCHEMBL3466960 | 0.80 | EED (0.50) | EEDZAP70KARS1HSD17B10ALOX15 | |
| SCHEMBL3469470 | 0.80 | EED (0.51) | EEDKDM4ELMNAFYNALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | claimed |
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | disclosed |
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | disclosed |