Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | PPARD | Q03181 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2824781 | 0.94 | PPARG (0.50) | PPARAPPARGPPARDSMN1; SMN2TDP1 | |
| SCHEMBL2820962 | 0.86 | PPARG (0.54) | PPARAPPARGPPARDSMN1; SMN2ALDH1A1 | |
| SCHEMBL3469302 | 0.80 | PPARG (0.42) | PPARAPPARGPPARDSMN1; SMN2TDP1 | |
| SCHEMBL28113645 | 0.70 | HTR2C (0.43) | PPARAPPARGPPARDSMN1; SMN2ALDH1A1 | |
| SCHEMBL20202573 | 0.69 | MAPK1 (0.51) | SMN1; SMN2TDP1ALDH1A1RAB9ANPC1 | |
| SCHEMBL26202134 | 0.69 | LMNA (0.53) | PPARAPPARGPPARDSMN1; SMN2TDP1 | |
| SCHEMBL257896 | 0.68 | TSHR (0.71) | SMN1; SMN2TDP1RAB9ANPC1CYP2C19 | |
| SCHEMBL2822359 | 0.68 | PPARA (0.72) | PPARAPPARGPPARD | |
| SCHEMBL13903094 | 0.67 | PPARA (0.55) | PPARAPPARGPPARDSMN1; SMN2TDP1 | |
| SCHEMBL7833852 | 0.67 | HPGD (0.53) | TDP1ALDH1A1HPGDNPSR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010071813-A1 | AGONISTS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR-α | ARYX THERAPEUTICS, INC. (US) | 2010-06-24 | — | — | WO | disclosed |