Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 7/20 | 0.57 |
| ▸ | PDE5A | O76074 | 1/20 | 0.56 |
| ▸ | PDE6A | P16499 | 1/20 | 0.56 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.56 |
| ▸ | PRKDC | P78527 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 5/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3467008 | 0.88 | FLT3 (0.48) | DYRK1APDE5APDE6APDE1BPDE3A | |
| SCHEMBL3467938 | 0.87 | PDE5A (0.67) | PDE5APDE6APDE1BPDE3APRKDC | |
| SCHEMBL3466485 | 0.83 | GRIA1 (0.60) | PDE5APDE6APDE1BPDE3ASLC6A3 | |
| SCHEMBL3467072 | 0.81 | PDE5A (0.59) | PDE5APDE6APDE1BPDE3ASLC6A3 | |
| SCHEMBL3469571 | 0.78 | PDE5A (0.63) | PDE5APDE6APDE1BPDE3ASLC6A3 | |
| SCHEMBL3467028 | 0.76 | PDE5A (0.60) | PDE5APDE6APDE1BPDE3ASLC6A3 | |
| SCHEMBL5400838 | 0.76 | DYRK1A (0.50) | DYRK1APIM1FYN | |
| SCHEMBL3467020 | 0.74 | PDE5A (0.60) | PDE5APDE6APDE1BPDE3ASLC6A3 | |
| SCHEMBL13734710 | 0.72 | DYRK1A (0.55) | DYRK1APRKDCPIM1 | |
| SCHEMBL16332001 | 0.72 | KCNH2 (0.48) | DYRK1APRKDCPIM1FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | claimed |
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | disclosed |