Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.67 |
| ▸ | PDE6A | P16499 | 1/20 | 0.67 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.67 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.52 |
| ▸ | STK4 | Q13043 | 1/20 | 0.50 |
| ▸ | STK3 | Q13188 | 1/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3469763 | 0.87 | DYRK1A (0.57) | PDE5APDE6APDE1BPDE3AGRIA1 | |
| SCHEMBL3467072 | 0.84 | PDE5A (0.59) | PDE5APDE6APDE1BPDE3AGRIA1 | |
| SCHEMBL3466485 | 0.84 | GRIA1 (0.60) | PDE5APDE6APDE1BPDE3ASTK4 | |
| SCHEMBL3469240 | 0.81 | PDE5A (1.00) | PDE5APDE6APDE1BPDE3ACYP3A4 | |
| SCHEMBL3473549 | 0.78 | PDE5A (0.67) | PDE5APDE6APDE1BPDE3ACYP1A2 | |
| SCHEMBL3467008 | 0.76 | FLT3 (0.48) | PDE5APDE6APDE1BPDE3A | |
| SCHEMBL3467020 | 0.76 | PDE5A (0.60) | PDE5APDE6APDE1BPDE3AGRIA1 | |
| SCHEMBL3467028 | 0.76 | PDE5A (0.60) | PDE5APDE6APDE1BPDE3AALDH1A1 | |
| SCHEMBL16881772 | 0.75 | PIK3CA (0.55) | CYP1A2CYP3A4TSHRMAPK1CYP2C19 | |
| SCHEMBL3470660 | 0.74 | FYN (0.54) | PDE5APDE6APDE1BPDE3AGRIA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | claimed |
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | disclosed |
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | disclosed |