Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.60 |
| ▸ | PDE6A | P16499 | 1/20 | 0.60 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.60 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.60 |
| ▸ | GRIA1 | P42261 | 14/20 | 0.58 |
| ▸ | CACNG2 | Q9Y698 | 2/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3467028 | 0.88 | PDE5A (0.60) | PDE5APDE6APDE1BPDE3AGRIA1 | |
| SCHEMBL3467072 | 0.86 | PDE5A (0.59) | PDE5APDE6APDE1BPDE3AGRIA1 | |
| SCHEMBL3466485 | 0.79 | GRIA1 (0.60) | PDE5APDE6APDE1BPDE3AGRIA1 | |
| SCHEMBL3469571 | 0.77 | PDE5A (0.63) | PDE5APDE6APDE1BPDE3AGRIA1 | |
| SCHEMBL6937711 | 0.77 | PDE5A (0.56) | PDE5APDE6APDE1BPDE3ASLC6A3 | |
| SCHEMBL3465801 | 0.77 | ALDH1A1 (0.51) | GRIA1 | |
| SCHEMBL3467938 | 0.76 | PDE5A (0.67) | PDE5APDE6APDE1BPDE3AGRIA1 | |
| SCHEMBL2486922 | 0.76 | PDE5A (0.58) | PDE5APDE6APDE1BPDE3A | |
| SCHEMBL3469240 | 0.75 | PDE5A (1.00) | PDE5APDE6APDE1BPDE3AGRIA1 | |
| SCHEMBL21377035 | 0.75 | GRIA1 (0.69) | GRIA1CACNG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | claimed |
| WO-2010069684-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-06-24 | — | — | WO | disclosed |