Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADH1A | P07327 | 4/20 | 0.44 |
| ▸ | ADH1C | P00326 | 3/20 | 0.44 |
| ▸ | ADH4 | P08319 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3954264 | 0.80 | ADH1A (0.69) | ADH1AADH1CADH4SLC6A2SLC6A4 | |
| SCHEMBL18476366 | 0.77 | ADH1A (0.66) | ADH1AADH1CADH4SLC6A2SLC6A4 | |
| SCHEMBL3955780 | 0.77 | ADH1A (0.44) | ADH1AADH1CADH4SLC6A2SLC6A4 | |
| SCHEMBL3687398 | 0.76 | ADH1A (0.74) | ADH1AADH1CADH4SLC6A2SLC6A4 | |
| SCHEMBL3955640 | 0.76 | ADH1A (0.64) | ADH1AADH1CADH4SLC6A2SLC6A4 | |
| SCHEMBL21038725 | 0.76 | SLC6A2 (0.55) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5269817 | 0.74 | ADH1A (0.41) | ADH1AADH1CADH4 | |
| SCHEMBL392115 | 0.74 | SLC6A4 (0.43) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL18475299 | 0.74 | SLC6A4 (0.43) | SLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL18428935 | 0.73 | SLC6A4 (0.43) | SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2215085-A2 | PYRIDINE AND PYRAZINE DERIVATIVES USEFUL IN THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | AstraZeneca AB (SE) | 2010-08-11 | — | — | EP | claimed |
| WO-2009053737-A2 | PYRIDINE AND PYRAZINE DERIVATIVES USEFUL IN THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2009-04-30 | — | — | WO | claimed |
| EP-2215085-A2 | PYRIDINE AND PYRAZINE DERIVATIVES USEFUL IN THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | AstraZeneca AB (SE) | 2010-08-11 | — | — | EP | disclosed |
| WO-2009053737-A2 | PYRIDINE AND PYRAZINE DERIVATIVES USEFUL IN THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2009-04-30 | — | — | WO | disclosed |