Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADH1A | P07327 | 4/20 | 0.44 |
| ▸ | ADH1C | P00326 | 3/20 | 0.44 |
| ▸ | ADH4 | P08319 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.30 |
| ▸ | GABRD | O14764 | 1/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.30 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.30 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.30 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.30 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.30 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.30 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.30 |
| ▸ | GABRE | P78334 | 1/20 | 0.30 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4579032 | 0.86 | — | — | |
| SCHEMBL2087045 | 0.84 | ADH1A (0.61) | ADH1AADH1CADH4 | |
| SCHEMBL3954264 | 0.81 | ADH1A (0.69) | ADH1AADH1CADH4SLC6A2SLC6A4 | |
| SCHEMBL18476366 | 0.78 | ADH1A (0.66) | ADH1AADH1CADH4SLC6A2SLC6A4 | |
| SCHEMBL3469985 | 0.77 | ADH1A (0.44) | ADH1AADH1CADH4SLC6A2SLC6A4 | |
| SCHEMBL3687398 | 0.77 | ADH1A (0.74) | ADH1AADH1CADH4SLC6A2SLC6A4 | |
| SCHEMBL3955640 | 0.76 | ADH1A (0.64) | ADH1AADH1CADH4SLC6A2SLC6A4 | |
| SCHEMBL5188572 | 0.73 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL18475300 | 0.71 | SLC6A2 (0.37) | SLC6A2SLC6A4SLC6A3GABRPGABRD | |
| SCHEMBL3955659 | 0.71 | ADH1A (0.36) | ADH1AADH1CADH4SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |