Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CFTR | P13569 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1012527 | 0.95 | KDM4E (0.73) | KDM4EALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL1012713 | 0.95 | KDM4E (0.73) | KDM4EALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL13028007 | 0.88 | KDM4E (0.46) | KDM4EALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL27122646 | 0.88 | KDM4E (0.54) | KDM4EALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL25037589 | 0.87 | KDM4E (0.65) | KDM4EALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL264389 | 0.86 | KDM4E (0.47) | KDM4EALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL263684 | 0.85 | KDM4E (0.45) | KDM4EALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL5052320 | 0.85 | CYP3A4 (0.46) | KDM4EALDH1A1MAPTTSHRPOLB | |
| SCHEMBL15966727 | 0.85 | KDM4E (0.45) | KDM4EMAPTHTTHDAC3HDAC1 | |
| Hydrochloric Acid SCHEMBL27984823 | 0.85 | KDM4E (0.46) | KDM4EALDH1A1GAAMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102311395-B | Quinazoline ring substituted diphenylurea derivative and its purpose | ZHANG AIHUA | 2014-04-16 | — | — | CN | disclosed |
| US-8343950-B2 | Cell surface tyrosine receptor kinase inhibitors; pyrogen-free; lung cancer; benign prostatic hyperplasia | CONCERT PHARMACEUTICALS, INC. (US) | 2013-01-01 | — | — | US | disclosed |
| CN-102746242-A | Synthesis method of 6, 7-substituent-4-aniline quinazoline | OMEGA CO LTD | 2012-10-24 | — | — | CN | disclosed |
| CN-101863844-B | Synthesis method of 6, 7-substituent-4-aniline quinazoline | XIANGZHEN BIOLOGY TECHNOLOGY CO LTD | 2012-10-03 | — | — | CN | disclosed |
| WO-2011147102-A1 | SYNTHETIC METHOD FOR 6,7-SUBSTITUENTS-4-ANILINE QUINAZOLINE | 翔真生物科技股份有限公司 (CN) | 2011-12-01 | — | — | WO | disclosed |
| US-20100267949-A1 | Method of Synthesizing 6,7-Substituted 4-Anilino Quinazoline | OMEGA MEDICAL TAIWAN LIMITED (TW) | 2010-10-21 | — | — | US | disclosed |
| CN-101863844-A | Synthesis method of 6, 7-substituent-4-aniline quinazoline | XIANGZHEN BIOLOGY TECHNOLOGY CO LTD | 2010-10-20 | — | — | CN | disclosed |
| US-20080166358-A1 | QUINAZOLINE DERIVATIVES AND METHODS OF TREATMENT | CONCERT PHARMACEUTICALS INC. (US) | 2008-07-10 | — | — | US | disclosed |
| WO-2008076949-A2 | QUINAZOLINE DERIVATIVES AND METHODS OF TREATMENT | CONCERT PHARMACEUTICALS INC. (US) | 2008-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267949-A1 | Method of Synthesizing 6,7-Substituted 4-Anilino Quinazoline | NQO2, ATIC, CYP3A7 | KDM4E 2145/4885ALDH1A1 878/4885GAA 927/4885 |
| US-20080166358-A1 | QUINAZOLINE DERIVATIVES AND METHODS OF TREATMENT | ABL1, FLT3, GRK5 | KDM4E 2268/4885ALDH1A1 3767/4885GAA 794/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.