Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.30 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8524121 | 0.75 | CLK1 (0.46) | HRH4PDE3BPDE3ADYRK1ACLK1 | |
| SCHEMBL4400860 | 0.75 | HRH4 (0.45) | HRH4PDE3BPDE3ADYRK1ACLK1 | |
| SCHEMBL20053810 | 0.72 | PTGS1 (0.47) | KDM4EALDH1A1GAAMAPT | |
| SCHEMBL3470490 | 0.71 | HRH4 (0.42) | HRH4PDE3BPDE3ADYRK1ACLK1 | |
| SCHEMBL12777861 | 0.71 | HRH4 (0.42) | HRH4PDE3BPDE3ADYRK1ACLK1 | |
| SCHEMBL6276392 | 0.71 | HRH4 (0.42) | HRH4PDE3BPDE3ADYRK1ACLK1 | |
| SCHEMBL5275762 | 0.71 | HRH4 (0.42) | HRH4PDE3BPDE3ADYRK1ACLK1 | |
| SCHEMBL25150638 | 0.70 | APP (0.32) | — | |
| SCHEMBL19957576 | 0.70 | HRH4 (0.42) | HRH4PDE3BPDE3ADYRK1ACLK1 | |
| SCHEMBL12223303 | 0.70 | DRD2 (0.47) | HRH4PDE3BPDE3ADYRK1ACLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200339569-A1 | 1,2,4-OXADIAZOLE DERIVATIVES AS HISTONE DEACETYLASE 6 INHIBITORS | ORYZON GENOMICS, S.A. (ES) | 2020-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200339569-A1 | 1,2,4-OXADIAZOLE DERIVATIVES AS HISTONE DEACETYLASE 6 INHIBITORS | HDAC6, HDAC1, HDAC3 | HRH4 836/4885PDE3B 1851/4885PDE3A 2075/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.