Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 14/20 | 0.73 |
| ▸ | KDM4C | Q9H3R0 | 8/20 | 0.73 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | POLB | P06746 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | GALK1 | P51570 | 4/20 | 0.55 |
| ▸ | BLM | P54132 | 4/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | ATG4B | Q9Y4P1 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | THRB | P10828 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | RECQL | P46063 | 3/20 | 0.55 |
| ▸ | ABL1 | P00519 | 2/20 | 0.55 |
| ▸ | MPI | P34949 | 2/20 | 0.55 |
| ▸ | RIN1 | Q13671 | 2/20 | 0.55 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3471911 | 0.85 | TDP2 (0.77) | TDP2KDM4CNPC1POLBMAPT | |
| SCHEMBL13272610 | 0.85 | TDP2 (1.00) | TDP2KDM4CNPC1POLBMAPT | |
| SCHEMBL2186422 | 0.79 | KDM4C (1.00) | TDP2KDM4CNPC1POLBMAPT | |
| SCHEMBL2180811 | 0.74 | TDP2 (0.77) | TDP2KDM4CNPC1POLBMAPT | |
| Hydrochloric Acid SCHEMBL3471096 | 0.72 | TDP2 (0.68) | TDP2KDM4CNPC1POLBMAPT | |
| SCHEMBL15032586 | 0.72 | TDP2 (1.00) | TDP2KDM4CNPC1POLBMAPT | |
| SCHEMBL15032576 | 0.70 | TGM2 (1.00) | TDP2KDM4CNPC1POLBMAPT | |
| SCHEMBL15032575 | 0.68 | TDP2 (1.00) | TDP2KDM4CNPC1POLBMAPT | |
| SCHEMBL2183892 | 0.67 | TDP2 (0.65) | TDP2KDM4CNPC1POLBMAPT | |
| SCHEMBL14020030 | 0.66 | TDP2 (0.73) | TDP2KDM4CNPC1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010072807-A2 | INHIBITORS OF CYSTATHIONINE BETA SYNTHASE TO REDUCE THE NEUROTOXIC OVERPRODUCTION OF ENDOGENOUS HYDROGEN SULFIDE | FONDATION JEROME LEJEUNE (FR) | 2010-07-01 | — | — | WO | disclosed |
| WO-2010072807-A2 | INHIBITORS OF CYSTATHIONINE BETA SYNTHASE TO REDUCE THE NEUROTOXIC OVERPRODUCTION OF ENDOGENOUS HYDROGEN SULFIDE | FONDATION JEROME LEJEUNE (FR) | 2010-07-01 | — | — | WO | disclosed |