Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 7/20 | 0.64 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.58 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.58 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.58 |
| ▸ | ABL1 | P00519 | 3/20 | 0.58 |
| ▸ | AXL | P30530 | 1/20 | 0.58 |
| ▸ | BRAF | P15056 | 7/20 | 0.57 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 2/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10234331 | 0.92 | MAPK13 (0.59) | MAPK13PTK2MAPK14MAPK12MAPK11 | |
| SCHEMBL3472215 | 0.91 | MAPK13 (0.77) | MAPK13PTK2MAPK14MAPK12MAPK11 | |
| SCHEMBL1410440 | 0.90 | MAPK13 (0.65) | MAPK13PTK2MAPK14MAPK12MAPK11 | |
| SCHEMBL1409947 | 0.90 | MAPK13 (0.64) | MAPK13PTK2MAPK14MAPK12MAPK11 | |
| SCHEMBL1410463 | 0.90 | MAPK13 (0.64) | MAPK13PTK2MAPK14MAPK12MAPK11 | |
| Trifluoroacetic Acid SCHEMBL1410295 | 0.89 | MAPK13 (0.60) | MAPK13PTK2MAPK14MAPK12MAPK11 | |
| SCHEMBL1410299 | 0.88 | MAPK13 (0.60) | MAPK13PTK2MAPK14MAPK12MAPK11 | |
| SCHEMBL1410621 | 0.87 | MAPK13 (0.59) | MAPK13PTK2MAPK14MAPK12MAPK11 | |
| SCHEMBL1409967 | 0.86 | MAPK14 (0.67) | MAPK13PTK2MAPK14MAPK12MAPK11 | |
| SCHEMBL3471536 | 0.86 | MAPK13 (0.62) | MAPK13PTK2MAPK14MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8207166-B2 | Substituted pyrazolyl urea derivatives useful in the treatment of cancer | BAYER HEALTHCARE LLC (US) | 2012-06-26 | — | — | US | disclosed |
| US-7838524-B2 | Substituted pyrazolyl urea derivatives useful in the treatment of cancer | BAYER HEALTHCARE LLC (US) | 2010-11-23 | — | — | US | disclosed |
| US-20080214545-A1 | Substituted Pyrazolyl Urea Derivatives Useful in the Treatment of Cancer | BAYER HEALTHCARE LLC | 2008-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214545-A1 | Substituted Pyrazolyl Urea Derivatives Useful in the Treatment of Cancer | UMPS, SLC14A1, TP53 | MAPK13 3031/4885PTK2 4304/4885MAPK14 2675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.