Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 13/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HCN1 | O60741 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3473323 | 0.92 | P2RX7 (0.83) | P2RX7 | |
| SCHEMBL14090859 | 0.92 | P2RX7 (0.83) | P2RX7 | |
| SCHEMBL3476055 | 0.91 | P2RX7 (0.84) | P2RX7 | |
| SCHEMBL3472355 | 0.91 | P2RX7 (0.84) | P2RX7 | |
| SCHEMBL13433825 | 0.83 | P2RX7 (0.70) | P2RX7 | |
| SCHEMBL13433818 | 0.83 | P2RX7 (0.70) | P2RX7 | |
| SCHEMBL13433824 | 0.83 | P2RX7 (0.70) | P2RX7 | |
| SCHEMBL3475587 | 0.83 | P2RX7 (0.70) | P2RX7 | |
| SCHEMBL3475785 | 0.83 | P2RX7 (0.69) | P2RX7 | |
| SCHEMBL3475207 | 0.82 | P2RX7 (1.00) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7671053-B2 | Benzamide inhibitors of the P2X7 receptor | PFIZER, INC. (US) | 2010-03-02 | — | — | US | disclosed |
| US-20090042886-A1 | Benzamide Inhibitors of the P2X7 Receptor | PFIZER, INC. (US) | 2009-02-12 | — | — | US | disclosed |
| US-7407956-B2 | Benzamide inhibitors of the P2X7 receptor | PFIZER, INC. (US) | 2008-08-05 | — | — | US | disclosed |
| US-20070281939-A1 | Benzamide Inhibitors of The P2X7 Receptor | PFIZER INC. | 2007-12-06 | — | — | US | disclosed |
| EP-1763353-A1 | COMBINATION THERAPIES UTILIZING BENZAMIDE INHIBITORS OF THE P2X<sb>7</sb> RECEPTOR | Warner-Lambert Company LLC (US) | 2007-03-21 | — | — | EP | disclosed |
| US-7176202-B2 | Benzamide inhibitors of the P2X7 receptor | PFIZER INC. (US) | 2007-02-13 | — | — | US | disclosed |
| US-20060040939-A1 | Benzamide inhibitors of the P2X, receptor | DOMBROSKI MARK A | 2006-02-23 | — | — | US | disclosed |
| US-20060018904-A1 | Combination therapies utilizing benzamide inhibitors of the P2X7 receptor | WARNER-LAMBERT COMPANY LLC | 2006-01-26 | — | — | US | disclosed |
| WO-2006003517-A1 | COMBINATION THERAPIES UTILIZING BENZAMIDE INHIBITORS OF THE P2X7 RECEPTOR | WARNER-LAMBERT COMPANY LLC (US) | 2006-01-12 | — | — | WO | disclosed |
| US-6974812-B2 | Benzamide inhibitors of the P2X7 Ereceptor | PFIZER INC. (US) | 2005-12-13 | — | — | US | disclosed |
| EP-1581232-A1 | 3-(3,5-DIOXO-4,5-DIHYDRO-3H-(1,2,4)TRIAZIN-2-YL)-BENZAMIDE DERIVATIVES AS P2X7-INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | Pfizer Products Inc. (US) | 2005-10-05 | — | — | EP | disclosed |
| US-20040180894-A1 | such as 2-chloro-N-(1-hydroxy-cycloheptylmethyl)-5-[4-(2-hydroxy-3-methoxy-propyl)-3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl]-benzamide; purinergic receptors (P2x7 E); for treatment of interleukin-1 associated disorders (rheumatoid arthritis) | PFIZER INC. | 2004-09-16 | — | — | US | disclosed |
| WO-2004058270-A1 | 3-(3,5-DIOXO-4,5-DIHYDRO-3H-(1,2,4)TRIAZIN-2-YL)-BENZAMIDE DERIVATIVES AS P2X7-INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | PFIZER PRODUCTS INC. (US) | 2004-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042886-A1 | Benzamide Inhibitors of the P2X7 Receptor | IL1R1, P2RY1, P2RX1 | P2RX7 7/4885HPGD 1218/4885TP53 1176/4885 |
| US-20040180894-A1 | such as 2-chloro-N-(1-hydroxy-cycloheptylmethyl)-5-[4-(2-hydroxy-3-methoxy-propyl)-3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl]-benzamide; purinergic receptors (P2x7 E); for treatment of interleukin-1 associated disorders (rheumatoid arthritis) | IL1R1, P2RY1, P2RX7 | P2RX7 3/4885HPGD 360/4885TP53 2361/4885 |
| US-20060018904-A1 | Combination therapies utilizing benzamide inhibitors of the P2X7 receptor | CSF3R, CSF1R, IL1R1 | P2RX7 72/4885HPGD 3610/4885TP53 1406/4885 |
| US-20070281939-A1 | Benzamide Inhibitors of The P2X7 Receptor | IL1R1, P2RY1, P2RX1 | P2RX7 7/4885HPGD 1218/4885TP53 1176/4885 |
| US-20060040939-A1 | Benzamide inhibitors of the P2X, receptor | IL1R1, P2RX1, P2RX3 | P2RX7 7/4885HPGD 1013/4885TP53 998/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.