Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | IRAK4 | Q9NWZ3 | 9/20 | 0.56 |
| ▸ | CTSD | P07339 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MGAM | O43451 | 1/20 | 0.51 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | SI | P14410 | 1/20 | 0.51 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.51 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3472180 | 0.80 | HPGD (0.66) | HTTHPGDALDH1A1GAAMEN1 | |
| SCHEMBL3471303 | 0.78 | KMT2A (0.67) | HTTHPGDIRAK4CTSDALDH1A1 | |
| SCHEMBL11013338 | 0.72 | ELANE (0.65) | HTTMEN1KMT2ALMNA | |
| SCHEMBL25956612 | 0.72 | IRAK4 (1.00) | IRAK4ALDH1A1IRAK1KMT2A | |
| SCHEMBL2629217 | 0.71 | F2 (0.58) | ALDH1A1MGAMAMY1AGAASI | |
| SCHEMBL22540485 | 0.71 | KMT2A (0.66) | HTTHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL15426094 | 0.71 | HPGD (0.60) | HPGDALDH1A1GAAKMT2A | |
| SCHEMBL27712404 | 0.71 | ELANE (0.76) | MEN1KMT2ALMNA | |
| SCHEMBL3472693 | 0.71 | ALDH3A1 (0.62) | HTTHPGDALDH1A1L3MBTL1GAA | |
| SCHEMBL8921250 | 0.69 | MAPT (0.53) | IRAK4ALDH1A1L3MBTL1GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100317706-A1 | HNF4alpha MODULATORS AND METHODS OF USE | BUMHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317706-A1 | HNF4alpha MODULATORS AND METHODS OF USE | HNF4A, NCOA4, NR4A3 | HTT 2121/4885HPGD 1711/4885IRAK4 1250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.