Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 5/20 | 0.70 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.70 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.70 |
| ▸ | SLC16A3 | O15427 | 3/20 | 0.40 |
| ▸ | SLC16A1 | P53985 | 3/20 | 0.40 |
| ▸ | MCTS1 | Q9ULC4 | 2/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 6/20 | 0.39 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.37 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | VNN1 | O95497 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3474540 | 0.84 | RXRA (0.69) | RXRANR1H2NR1H3KCNK3TRPV1 | |
| SCHEMBL3471757 | 0.82 | RXRA (1.00) | RXRANR1H2NR1H3KCNK3 | |
| SCHEMBL3473250 | 0.82 | RXRA (0.46) | RXRANR1H2NR1H3SLC16A3SLC16A1 | |
| SCHEMBL14624825 | 0.78 | RXRA (0.45) | RXRANR1H2NR1H3SLC16A3SLC16A1 | |
| SCHEMBL3472537 | 0.77 | RXRA (0.83) | RXRANR1H2NR1H3SLC16A3SLC16A1 | |
| SCHEMBL3471298 | 0.75 | RXRA (0.63) | RXRANR1H2NR1H3KCNK3TRPV1 | |
| SCHEMBL3472176 | 0.74 | RXRA (0.72) | RXRANR1H2NR1H3NPC1RAB9A | |
| SCHEMBL3471064 | 0.73 | RXRA (0.68) | RXRANR1H2NR1H3SLC16A3SLC16A1 | |
| SCHEMBL3472231 | 0.72 | RXRA (0.56) | RXRANR1H2NR1H3SLC16A3SLC16A1 | |
| SCHEMBL3471213 | 0.72 | RXRA (0.52) | RXRANR1H2NR1H3TRPV1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703805-B2 | Modulators of LXR | EXELIXIS PATENT COMPANY LLC (US) | 2014-04-22 | — | — | US | claimed |
| US-8703805-B2 | Modulators of LXR | EXELIXIS PATENT COMPANY LLC (US) | 2014-04-22 | — | — | US | disclosed |
| US-8703805-B2 | Modulators of LXR | EXELIXIS PATENT COMPANY LLC (US) | 2014-04-22 | — | — | US | disclosed |
| US-8703805-B2 | Modulators of LXR | EXELIXIS PATENT COMPANY LLC (US) | 2014-04-22 | — | — | US | disclosed |
| CN-101248048-B | Imidazole based LXR modulators | EXELIXIS INC | 2013-08-28 | — | — | CN | disclosed |
| US-20100331295-A1 | MODULATORS OF LXR | EXELIXIS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100331295-A1 | MODULATORS OF LXR | EXELIXIS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100331295-A1 | MODULATORS OF LXR | EXELIXIS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331295-A1 | MODULATORS OF LXR | NR1H2, NR1H3, NR1H4 | RXRA 18/4885NR1H2 1/4885NR1H3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.