Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.63 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.63 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.63 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | PKLR | P30613 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.36 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.36 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3475580 | 0.81 | NR1H2 (0.43) | RXRANR1H2NR1H3PKMPKLR | |
| SCHEMBL3471757 | 0.78 | RXRA (1.00) | RXRANR1H2NR1H3PTGS1PTGS2 | |
| SCHEMBL3474540 | 0.77 | RXRA (0.69) | RXRANR1H2NR1H3PTGS2KCNK3 | |
| SCHEMBL14624785 | 0.76 | PTGS2 (0.46) | RXRANR1H2NR1H3PTGS1PTGS2 | |
| SCHEMBL3473492 | 0.75 | RXRA (0.70) | RXRANR1H2NR1H3KCNK3RAB9A | |
| SCHEMBL3472176 | 0.75 | RXRA (0.72) | RXRANR1H2NR1H3PTGS1PTGS2 | |
| SCHEMBL3472178 | 0.75 | RXRA (0.58) | RXRANR1H2NR1H3HDAC3HDAC1 | |
| SCHEMBL3470788 | 0.75 | RXRA (0.57) | RXRANR1H2NR1H3GUCY1B2GUCY1A2 | |
| SCHEMBL3474522 | 0.74 | RXRA (0.52) | RXRANR1H2NR1H3GUCY1B2GUCY1A2 | |
| SCHEMBL12978968 | 0.70 | HDAC3 (0.48) | RXRANR1H2NR1H3PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703805-B2 | Modulators of LXR | EXELIXIS PATENT COMPANY LLC (US) | 2014-04-22 | — | — | US | disclosed |
| US-20100331295-A1 | MODULATORS OF LXR | EXELIXIS, INC. (US) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331295-A1 | MODULATORS OF LXR | NR1H2, NR1H3, NR1H4 | RXRA 18/4885NR1H2 1/4885NR1H3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.