Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3470000 | 0.79 | HPGD (0.49) | HPGDALDH1A1CYP3A4KMT2AMEN1 | |
| SCHEMBL3473032 | 0.77 | ALDH1A1 (0.49) | HPGDALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL1944831 | 0.76 | ALDH1A1 (0.63) | HPGDALDH1A1CYP3A4KMT2AMEN1 | |
| SCHEMBL6243233 | 0.76 | KMT2A (0.55) | HPGDALDH1A1CYP3A4KMT2AMEN1 | |
| SCHEMBL319866 | 0.74 | KMT2A (0.73) | HPGDALDH1A1CYP3A4KMT2AMEN1 | |
| SCHEMBL31268558 | 0.74 | KDM4C (0.44) | HPGDALDH1A1KMT2AMEN1GAA | |
| SCHEMBL6518554 | 0.72 | HPGD (0.51) | HPGDALDH1A1CYP3A4KMT2AMEN1 | |
| SCHEMBL6518558 | 0.72 | HPGD (0.51) | HPGDALDH1A1CYP3A4KMT2AMEN1 | |
| SCHEMBL2183881 | 0.72 | GAA (0.58) | HPGDALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL31268559 | 0.71 | KDM4C (0.45) | ALDH1A1KMT2AMEN1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010072807-A2 | INHIBITORS OF CYSTATHIONINE BETA SYNTHASE TO REDUCE THE NEUROTOXIC OVERPRODUCTION OF ENDOGENOUS HYDROGEN SULFIDE | FONDATION JEROME LEJEUNE (FR) | 2010-07-01 | — | — | WO | disclosed |
| WO-2010072807-A2 | INHIBITORS OF CYSTATHIONINE BETA SYNTHASE TO REDUCE THE NEUROTOXIC OVERPRODUCTION OF ENDOGENOUS HYDROGEN SULFIDE | FONDATION JEROME LEJEUNE (FR) | 2010-07-01 | — | — | WO | disclosed |