SCHEMBL3474207

SCHEMBL3474207

CC(=O)Nc1ccc(Br)cc1C

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.60
MEN1 O00255 3/20 0.60
KMT2A Q03164 3/20 0.60
ALDH1A1 P00352 7/20 0.60
SIGMAR1 Q99720 2/20 0.58
DHODH Q02127 1/20 0.55
HPGD P15428 2/20 0.55
NPC1 O15118 1/20 0.54
RAB9A P51151 1/20 0.54
GAA P10253 1/20 0.54
HTT P42858 2/20 0.53
NPSR1 Q6W5P4 1/20 0.53
CYP1A2 P05177 1/20 0.51
CYP3A4 P08684 1/20 0.51
CYP2D6 P10635 1/20 0.51
CYP2C9 P11712 1/20 0.51
CYP2C19 P33261 1/20 0.51
NPY1R P25929 1/20 0.50
NPY2R P49146 1/20 0.50
THRB P10828 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30526578 1.00 MAPT (0.60) MAPTMEN1KMT2AALDH1A1SIGMAR1
SCHEMBL30051993 0.86 MAPT (0.71) MAPTMEN1KMT2AALDH1A1SIGMAR1
SCHEMBL3440627 0.86 ALDH1A1 (0.59) MAPTMEN1KMT2AALDH1A1SIGMAR1
SCHEMBL4808346 0.85 ALDH1A1 (0.56) MAPTMEN1KMT2AALDH1A1HPGD
SCHEMBL1284518 0.84 ALDH1A1 (0.64) MAPTMEN1KMT2AALDH1A1HPGD
SCHEMBL18324579 0.83 SIGMAR1 (0.59) MAPTMEN1KMT2AALDH1A1SIGMAR1
SCHEMBL31236186 0.82 ALDH1A1 (0.62) MAPTMEN1KMT2AALDH1A1HPGD
SCHEMBL31236185 0.82 ALDH1A1 (0.62) MAPTMEN1KMT2AALDH1A1HPGD
SCHEMBL29572629 0.82 ALDH1A1 (0.62) MAPTMEN1KMT2AALDH1A1HPGD
SCHEMBL28724549 0.82 ALDH1A1 (0.62) MAPTMEN1KMT2AALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025137606-A1 (HETERO)ARYL NRF2 PROTEIN DEGRADERS GANYMEDE ONCOLOGY, INC. (US) 2025-06-26 WO disclosed
WO-2025111547-A1 2,3-DIHYDROPYROLLOPYRIDINE CARBOXAMIDE COMPOUNDS AND METHODS OF USE THEREOF RGENTA THERAPEUTICS, INC. (US) 2025-05-30 WO disclosed
US-20250026766-A1 Thiazolopyridyl Amide Derivatives as DNA Polymerase Theta Inhibitors BEIGENE, LTD. (KY) 2025-01-23 US disclosed
WO-2023134708-A1 THIAZOLOPYRIDYL AMIDE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS BEIGENE , LTD. (KY) 2023-07-20 WO disclosed
WO-2021041237-A1 THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS Terns, Inc. (US) 2021-03-04 WO disclosed
CN-108147972-B Preparation method of vipatavir intermediate and analogue thereof 成都西岭源药业有限公司 2020-07-10 CN disclosed
EP-2874632-B1 TRIAZINE COMPOUND HAVING PI3K-ALPHA AND MTOR INHIBITING ACTIVITY SPHAERA PHARMA PTE LTD (SG) 2020-06-17 EP disclosed
US-9630958-B2 Triazine compounds SPHAERA PHARMA PTE. LTD. (SG) 2017-04-25 US disclosed
US-20150197515-A1 NOVEL TRIAZINE COMPOUNDS SPHAERA PHARMA PTE. LTD. (SG) 2015-07-16 US disclosed
CN-103787895-A Production process for synthesizing 4-bromo-2-methylaniline ANHUI HUARUN PAINTS CO LTD 2014-05-14 CN disclosed
EP-1127060-A1 HYDROBORONATION PROCESS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2001-08-29 EP disclosed
EP-1090907-A1 A process for the production of amides from amines COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2001-04-11 EP disclosed
US-6215024-B1 ACYLATING AMINE WITH ACETIC, PROPIONIC AND/OR BUTYRIC ACID IN PRESENCE OF METAL ION EXCHANGED MONTMORILLIONITE CLAY CATALYST IN SOLVENT; AMIDATION COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2001-04-10 US disclosed
WO-2001017943-A1 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE TARGACEPT, INC. (US) 2001-03-15 WO disclosed
WO-2000063207-A1 PESTICIDAL INDAZOLE OR BENZOTRIAZOLE DERIVATIVES SYNGENTA LIMITED (GB) 2000-10-26 WO disclosed
WO-2000027853-A1 HYDROBORONATION PROCESS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2000-05-18 WO disclosed
WO-1993012795-A1 QUINAZOLIN-4(3H)-ONE DERIVATIVES AS ANTICOCCIDIAL AGENTS GLAZER EDWARD A (US) 1993-07-08 WO disclosed
US-4920224-A CHEMICAL INTERMEDIATES PFIZER INC. (US) 1990-04-24 US disclosed
US-4849518-A ANTIPROTOZOA IN POULTRY PFIZER INC. (US) 1989-07-18 US disclosed
US-4762838-A Quinazolin-4(3H)-one derivatives as anticoccidial agents PFIZER INC. (US) 1988-08-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250026766-A1 Thiazolopyridyl Amide Derivatives as DNA Polymerase Theta Inhibitors POLQ, POLK, POLI MAPT 544/4885MEN1 3950/4885KMT2A 849/4885
US-20150197515-A1 NOVEL TRIAZINE COMPOUNDS MTOR, PIK3R5, PIK3R2 MAPT 2037/4885MEN1 3314/4885KMT2A 2996/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.