Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 17/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3475817 | 0.88 | GRM2 (0.36) | GRM2 | |
| SCHEMBL7819300 | 0.87 | GRM2 (0.39) | GRM2CNR2 | |
| SCHEMBL3469755 | 0.86 | CNR1 (0.37) | GRM2CNR2 | |
| SCHEMBL3476991 | 0.84 | GRM2 (0.35) | GRM2 | |
| SCHEMBL3475849 | 0.84 | CNR2 (0.37) | GRM2DPP4CNR2 | |
| SCHEMBL3476240 | 0.84 | GRM2 (0.39) | GRM2 | |
| SCHEMBL3474988 | 0.83 | GRM2 (0.35) | GRM2 | |
| SCHEMBL3475357 | 0.82 | GRM2 (0.43) | GRM2CNR2 | |
| SCHEMBL3475397 | 0.82 | GRM2 (0.36) | GRM2 | |
| SCHEMBL3476138 | 0.81 | GRM2 (0.38) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010141360-A1 | BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2010-12-09 | — | — | WO | claimed |
| WO-2010141360-A1 | BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2010-12-09 | — | — | WO | disclosed |
| WO-2010141360-A1 | BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2010-12-09 | — | — | WO | disclosed |