Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | PPARA | Q07869 | 11/20 | 0.44 |
| ▸ | PPARG | P37231 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | FABP2 | P12104 | 1/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16326512 | 0.85 | KDM4E (0.45) | MAP4K4KDM4EALDH1A1HSD17B10MAPT | |
| SCHEMBL3474425 | 0.81 | MAP4K4 (0.48) | MAP4K4KDM4EALDH1A1HSD17B10PPARA | |
| SCHEMBL2824496 | 0.81 | MAP4K4 (0.61) | MAP4K4ALDH1A1PPARAPPARGMAPT | |
| SCHEMBL1046555 | 0.81 | MAP4K4 (0.48) | MAP4K4KDM4EALDH1A1HSD17B10PPARA | |
| SCHEMBL201045 | 0.79 | LMNA (0.50) | MAP4K4PPARAPPARGKMT2APPARD | |
| SCHEMBL13750249 | 0.79 | MAP4K4 (0.46) | MAP4K4KDM4EALDH1A1HSD17B10PPARA | |
| SCHEMBL3475308 | 0.79 | MAP4K4 (0.46) | MAP4K4KDM4EALDH1A1HSD17B10PPARA | |
| Hydrochloric Acid SCHEMBL199908 | 0.78 | LMNA (0.49) | MAP4K4PPARAPPARGKMT2APPARD | |
| SCHEMBL3524458 | 0.78 | MAP4K4 (0.45) | MAP4K4KDM4EALDH1A1HSD17B10PPARA | |
| SCHEMBL3476037 | 0.78 | MAP4K4 (0.45) | MAP4K4PPARAPPARGMAPTCYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7754188-B2 | Radiolabeled cannabinoid-1 receptor modulators | MERCK SHARP & DOHME CORP. (US) | 2010-07-13 | — | — | US | disclosed |
| US-20080076805-A1 | Acyclic Hydrazides as Cannabinoid Receptor Modulators | MERCK SHARP & DOHME CORP. | 2008-03-27 | — | — | US | disclosed |
| EP-1641493-A4 | RADIOLABELED CANNABINOID-1 RECEPTOR MODULATORS | MERCK & CO INC (US) | 2007-10-31 | — | — | EP | disclosed |
| CN-101048368-A | Acyclic hydrazides as cannabinoid receptor modulators | MERCK & CO INC (US) | 2007-10-03 | — | — | CN | disclosed |
| EP-1807388-A2 | ACYCLIC HYDRAZIDES AS CANNABINOID RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2007-07-18 | — | — | EP | disclosed |
| US-20060115425-A1 | Substituted amides | MERCK SHARP & DOHME CORP. | 2006-06-01 | — | — | US | disclosed |
| WO-2006041797-A2 | ACYCLIC HYDRAZIDES AS CANNABINOID RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2006-04-20 | — | — | WO | disclosed |
| EP-1641493-A1 | RADIOLABELED CANNABINOID-1 RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2006-04-05 | — | — | EP | disclosed |
| WO-2005009479-A1 | RADIOLABELED CANNABINOID-1 RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2005-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076805-A1 | Acyclic Hydrazides as Cannabinoid Receptor Modulators | CNR1, CNR2, FAAH | MAP4K4 2241/4885KDM4E 2167/4885ALDH1A1 2539/4885 |
| US-20060115425-A1 | Substituted amides | CNR1, CNR2, FAAH | MAP4K4 2487/4885KDM4E 1953/4885ALDH1A1 2485/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.