Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CYP2A13 | Q16696 | 6/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | RRM2 | P31350 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2494138 | 0.99 | CYP2C9 (0.39) | CYP2C9HSD17B10ALOX15CYP2A13CNR2 | |
| SCHEMBL16009577 | 0.72 | TLR8 (0.36) | JAK2JAK3 | |
| SCHEMBL4731601 | 0.70 | CNR2 (0.55) | CYP2C9HSD17B10ALOX15CYP2A13CNR2 | |
| SCHEMBL5474572 | 0.68 | NUDT1 (0.43) | JAK2JAK3 | |
| SCHEMBL4729559 | 0.67 | PIK3CA (0.49) | HSD17B10CNR2SMN1; SMN2RAB9AKDM4E | |
| SCHEMBL27854561 | 0.66 | CYP2A13 (0.53) | CYP2C9HSD17B10ALOX15CYP2A13METAP2 | |
| SCHEMBL30605619 | 0.66 | NCF1 (0.54) | JAK2SMN1; SMN2NPC1RAB9ACYP3A4 | |
| SCHEMBL16524047 | 0.66 | SMN1; SMN2 (0.42) | CYP2C9HSD17B10ALOX15CYP2A13SMN1; SMN2 | |
| SCHEMBL2236500 | 0.66 | NCF1 (0.54) | JAK2SMN1; SMN2NPC1RAB9ACYP3A4 | |
| SCHEMBL24858099 | 0.66 | CXCR4 (0.41) | ALOX15CYP2A13SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014020531-A1 | IMIDAZO[1,2-B]PYRIDAZIN-6-AMINE DERIVATIVES AS KINASE JAK-2 INHIBITORS | CELON PHARMA S.A. (PL) | 2014-02-06 | — | — | WO | disclosed |
| WO-2010074947-A1 | AMINO PYRAZOLE COMPOUND | ELI LILLY AND COMPANY (US) | 2010-07-01 | — | — | WO | disclosed |