Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2C
The experimentally established mechanism targets of Tetrahydrozoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 3/20 | 1.00 |
| ▸ | ADRA1A known ✓ | P35348 | 3/20 | 1.00 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.54 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.97 |
| ▸ | BLM | P54132 | 1/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.97 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.97 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrozoline SCHEMBL30292036 | 1.00 | ADRA2A (1.00) | ADRA2AADRA1ACYP2D6HTR1AOPRM1 | |
| Tetrahydrozoline SCHEMBL29603648 | 1.00 | ADRA2A (1.00) | ADRA2AADRA1ACYP2D6HTR1AOPRM1 | |
| Tetrahydrozoline SCHEMBL29393067 | 0.98 | CYP2D6 (1.00) | ADRA2AADRA1ACYP2D6HTR1AOPRM1 | |
| Tetrahydrozoline SCHEMBL25702 | 0.98 | CYP2D6 (1.00) | ADRA2AADRA1ACYP2D6HTR1AOPRM1 | |
| Tetrahydrozoline SCHEMBL871337 | 0.98 | ADRA1A (0.97) | ADRA2AADRA1ACYP2D6HTR1AOPRM1 | |
| Tetrahydrozoline SCHEMBL23496614 | 0.98 | CYP2D6 (1.00) | ADRA2AADRA1ACYP2D6HTR1AOPRM1 | |
| Tetrahydrozoline SCHEMBL9296922 | 0.97 | CYP2D6 (0.97) | ADRA2AADRA1ACYP2D6HTR1AOPRM1 | |
| Tetrahydrozoline SCHEMBL1140101 | 0.92 | ADRA1A (0.85) | ADRA2AADRA1ACYP2D6HTR1AOPRM1 | |
| SCHEMBL10930958 | 0.91 | CYP2D6 (0.83) | ADRA2AADRA1ACYP2D6HTR1AOPRM1 | |
| Tetrahydrozoline SCHEMBL1512892 | 0.90 | ADRA1A (0.81) | ADRA2AADRA1ACYP2D6HTR1AOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 6475 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4724079-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION | Stealth BioTherapeutics Inc. (US) | 2026-04-15 | — | — | EP | claimed |
| EP-4704839-A2 | IMIDAZOLE CONTAINING COMPOUNDS, DERIVATIVES THEREFORE, AND USES THEREOF | ALPHERABIO LLC (US) | 2026-03-11 | — | — | EP | claimed |
| US-12569451-B2 | Bio-inspired tissue-adhesive hydrogel patch and uses thereof | Cellartgen Inc. (KR) | 2026-03-10 | — | — | US | claimed |
| US-20260048096-A1 | METHODS AND COMPOSITIONS FOR PRESERVING THE RETINAL OUTER NUCLEAR LAYER (ONL), PHOTORECEPTORS, AND RETINAL THICKNESS | STEALTH BIOTHERAPEUTICS INC. (US) | 2026-02-19 | — | — | US | claimed |
| US-12543500-B2 | Light emitting element | SAMSUNG DISPLAY CO., LTD. (KR) | 2026-02-03 | — | — | US | claimed |
| US-12490932-B2 | Ophthalmic drug delivery | EYENOVIA, INC. (US) | 2025-12-09 | — | — | US | claimed |
| US-20250255755-A1 | WOUND HEALING DEVICE AND METHODS FOR WOUND HEALING | SINUS CLEAR INNOVATIONS LLC (US) | 2025-08-14 | — | — | US | claimed |
| EP-4596049-A2 | PEPTIDE FOR USE IN PREVENTING OR TREATING MACULAR DEGENERATION | Stealth BioTherapeutics Inc. (US) | 2025-08-06 | — | — | EP | claimed |
| US-20250213647-A1 | CHEMOKINE RECEPTORS AND ALPHA1 ADRENERGIC RECEPTORS/VASOPRESSIN RECEPTORS 1A HETEROMERS AS DRUG TARGETS FOR DISEASE | UNIVERSITY OF SOUTH FLORIDA | 2025-07-03 | — | — | US | claimed |
| CN-120114603-A | Compound pharmaceutical composition for treating presbyopia as well as preparation method, application and preparation thereof | 立生医药(苏州)有限公司 | 2025-06-10 | — | — | CN | claimed |
| EP-0454617-A1 | Treatment of sinus headache | WARNER-LAMBERT COMPANY (US) | 1991-10-30 | — | — | EP | claimed |
| US-4853402-A | 2-SUBSTITUTED-2-IMIDAZOLINES | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 1989-08-01 | — | — | US | claimed |
| EP-0086428-B1 | ANTIDIARRHOEA VETERINARY COMPOSITION, ITS PRODUCTION AND ORAL DOSER CONTAINING IT | BEECHAM GROUP PLC (GB) | 1987-07-29 | — | — | EP | claimed |
| US-4603131-A | Method and composition for treating and preventing irritation of the mucous membranes of the nose | BERNSTEIN, JOEL E. | 1986-07-29 | — | — | US | claimed |
| EP-0170193-A2 | Feedstuff additive for the growth promoting of agricultural useful animals | BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) | 1986-02-05 | — | — | EP | claimed |
| US-4557934-A | ALONG WITH A DIOL PYRROLIDONE OR AN AZACYCLOPENTAN-2-ONE | THE PROCTER & GAMBLE COMPANY (US) | 1985-12-10 | — | — | US | claimed |
| EP-0025269-B1 | ANTI-DIARRHOEA VETERINARY COMPOSITION | BEECHAM GROUP PLC (GB) | 1985-11-13 | — | — | EP | claimed |
| US-4474752-A | DIAMINE MODIFIED POLYOXYETHYLENE-POLYOXYPROPYLENE COPOLYMER | MERCK & CO., INC. (US) | 1984-10-02 | — | — | US | claimed |
| EP-0086428-A1 | Antidiarrhoea veterinary composition, its production and oral doser containing it | BEECHAM GROUP PLC (GB) | 1983-08-24 | — | — | EP | claimed |
| US-3933999-A | 1-METHYL-2-(2-(ALPHA-METHYL-P -CHLORODIPHENYLMETHOXY)ETHYL)PYRROLIDONE, RHINITIS, VASOCONSTRICTOR | SANDOZ LTD., (SANDOZ AG) (CH) | 1976-01-20 | — | — | US | claimed |