SCHEMBL3476272

SCHEMBL3476272

Cc1nn(C)c2nc(=O)n(C3CCCCC3)c(=O)c-2[n+]1[O-]

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP2 O95551 4/20 0.40
GAA P10253 1/20 0.35
ALOX15 P16050 1/20 0.35
CRHBP P24387 1/20 0.33
CRHR2 Q13324 1/20 0.33
RXFP1 Q9HBX9 1/20 0.33
GSK3A P49840 1/20 0.33
GSK3B P49841 1/20 0.33
HCAR1 Q9BXC0 2/20 0.32
OPRM1 P35372 2/20 0.32
OPRK1 P41145 2/20 0.32
OGFRL1 Q5TC84 2/20 0.32
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
ALDH1A1 P00352 2/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C9 P11712 1/20 0.32
CYP2C19 P33261 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3471299 0.86 TDP2 (0.43) TDP2GAAALOX15CRHBPCRHR2
SCHEMBL3472911 0.85 TDP2 (0.37) TDP2GAAALOX15CRHBPCRHR2
SCHEMBL3474651 0.76 TDP2 (0.47) TDP2RXFP1MEN1KMT2AALDH1A1
SCHEMBL3471025 0.73 TDP2 (0.56) TDP2GAAALOX15CRHBPCRHR2
SCHEMBL3473513 0.72 TDP2 (0.54) TDP2CYP1A2SMN1; SMN2SIRT1KDM4E
SCHEMBL3471235 0.70 TDP2 (0.74) TDP2GAAALOX15CRHBPCRHR2
SCHEMBL3473636 0.69 TDP2 (0.48) TDP2GAAALOX15CRHBPCRHR2
SCHEMBL3473787 0.67 TDP2 (0.51) TDP2RXFP1MEN1KMT2AALDH1A1
SCHEMBL3471912 0.64 TDP2 (0.66) TDP2GAAALOX15CRHBPCRHR2
SCHEMBL3474307 0.63 TDP2 (0.36) TDP2GAAALOX15CRHBPCRHR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010072807-A2 INHIBITORS OF CYSTATHIONINE BETA SYNTHASE TO REDUCE THE NEUROTOXIC OVERPRODUCTION OF ENDOGENOUS HYDROGEN SULFIDE FONDATION JEROME LEJEUNE (FR) 2010-07-01 WO claimed
WO-2010072807-A2 INHIBITORS OF CYSTATHIONINE BETA SYNTHASE TO REDUCE THE NEUROTOXIC OVERPRODUCTION OF ENDOGENOUS HYDROGEN SULFIDE FONDATION JEROME LEJEUNE (FR) 2010-07-01 WO disclosed
WO-2010072807-A2 INHIBITORS OF CYSTATHIONINE BETA SYNTHASE TO REDUCE THE NEUROTOXIC OVERPRODUCTION OF ENDOGENOUS HYDROGEN SULFIDE FONDATION JEROME LEJEUNE (FR) 2010-07-01 WO disclosed