Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 8/20 | 0.66 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 3/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 3/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MPI | P34949 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13272610 | 0.80 | TDP2 (1.00) | TDP2KDM4CMEN1KMT2ARAF1 | |
| SCHEMBL3471919 | 0.79 | TDP2 (0.75) | TDP2KDM4CKMT2ARAF1MAP2K1 | |
| SCHEMBL3471025 | 0.77 | TDP2 (0.56) | TDP2KDM4CGAAALOX15MEN1 | |
| SCHEMBL3471235 | 0.74 | TDP2 (0.74) | TDP2KDM4CGAAALOX15MEN1 | |
| SCHEMBL3473636 | 0.73 | TDP2 (0.48) | TDP2KDM4CGAAALOX15MEN1 | |
| SCHEMBL3474479 | 0.69 | TDP2 (1.00) | TDP2KDM4CMEN1KMT2ARAF1 | |
| SCHEMBL3471911 | 0.69 | TDP2 (0.77) | TDP2KDM4CMEN1KMT2ARAF1 | |
| SCHEMBL3471993 | 0.67 | TDP2 (0.73) | TDP2KDM4CMEN1KMT2ARAF1 | |
| SCHEMBL3476272 | 0.64 | TDP2 (0.40) | TDP2GAAALOX15MEN1KMT2A | |
| SCHEMBL3474700 | 0.64 | TDP2 (0.37) | TDP2GAAALOX15MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010072807-A2 | INHIBITORS OF CYSTATHIONINE BETA SYNTHASE TO REDUCE THE NEUROTOXIC OVERPRODUCTION OF ENDOGENOUS HYDROGEN SULFIDE | FONDATION JEROME LEJEUNE (FR) | 2010-07-01 | — | — | WO | disclosed |
| WO-2010072807-A2 | INHIBITORS OF CYSTATHIONINE BETA SYNTHASE TO REDUCE THE NEUROTOXIC OVERPRODUCTION OF ENDOGENOUS HYDROGEN SULFIDE | FONDATION JEROME LEJEUNE (FR) | 2010-07-01 | — | — | WO | disclosed |