Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 11/20 | 0.53 |
| ▸ | ANPEP | P15144 | 7/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PEPD | P12955 | 2/20 | 0.33 |
| ▸ | XPNPEP1 | Q9NQW7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1251167 | 0.86 | ATM (0.42) | MMP2ANPEP | |
| SCHEMBL1251161 | 0.86 | ATM (0.42) | MMP2ANPEP | |
| SCHEMBL1251163 | 0.86 | ATM (0.42) | MMP2ANPEP | |
| SCHEMBL21682443 | 0.86 | ATM (0.42) | MMP2ANPEP | |
| SCHEMBL6917231 | 0.86 | ATM (0.42) | MMP2ANPEP | |
| SCHEMBL3846917 | 0.83 | MMP2 (0.41) | MMP2ANPEP | |
| SCHEMBL21702575 | 0.83 | MMP2 (0.49) | MMP2ANPEPALDH1A1CA12CA1 | |
| SCHEMBL31556015 | 0.82 | MMP2 (0.47) | MMP2ANPEPALDH1A1PEPDXPNPEP1 | |
| SCHEMBL7447674 | 0.82 | MMP2 (0.47) | MMP2ANPEPALDH1A1PEPDXPNPEP1 | |
| SCHEMBL3013548 | 0.82 | MMP2 (0.47) | MMP2ANPEPALDH1A1PEPDXPNPEP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2776409-A1 | MACROCYCLIC COMPOUNDS FOR INHIBITION OF INHIBITORS OF APOPTOSIS | Ensemble Therapeutics (US) | 2014-09-17 | — | — | EP | disclosed |
| WO-2013071035-A1 | MACROCYCLIC COMPOUNDS FOR INHIBITION OF INHIBITORS OF APOPTOSIS | ENSEMBLE THERAPEUTICS (US) | 2013-05-16 | — | — | WO | disclosed |
| EP-2215085-A2 | PYRIDINE AND PYRAZINE DERIVATIVES USEFUL IN THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | AstraZeneca AB (SE) | 2010-08-11 | — | — | EP | disclosed |
| WO-2009053737-A2 | PYRIDINE AND PYRAZINE DERIVATIVES USEFUL IN THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2009-04-30 | — | — | WO | disclosed |
| EP-2035395-A2 | NOVEL PROCESSES FOR THE PREPARATION OF DPP IV INHIBITORS | Glenmark Pharmaceuticals S.A. (CH) | 2009-03-18 | — | — | EP | disclosed |
| WO-2008001195-A2 | NOVEL PROCESSES FOR THE PREPARATION OF DPP IV INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (US) | 2008-01-03 | — | — | WO | disclosed |