Sugi Predict

Sugi Predict / Compounds / SCHEMBL21702575

SCHEMBL21702575

SCHEMBL21702575

CCOC(=O)N1C[C@@H](OS(C)(=O)=O)C[C@@H]1C(=O)OC

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MMP2 P08253 4/20 0.49
▸ ANPEP P15144 4/20 0.49
▸ CA12 O43570 1/20 0.36
▸ CA1 P00915 1/20 0.36
▸ CA2 P00918 1/20 0.36
▸ CA9 Q16790 1/20 0.36
▸ MEN1 O00255 1/20 0.36
▸ KMT2A Q03164 1/20 0.36
▸ ALDH1A1 P00352 2/20 0.36
▸ GAA P10253 4/20 0.34
▸ HCRTR2 O43614 1/20 0.33
▸ PEPD P12955 2/20 0.33
▸ CYP3A4 P08684 2/20 0.33
▸ MAPT P10636 2/20 0.33
▸ XPNPEP1 Q9NQW7 1/20 0.32
▸ NR1H2 P55055 1/20 0.32
▸ NR1H3 Q13133 1/20 0.32
▸ TSHR P16473 2/20 0.32
▸ USP2 O75604 1/20 0.32
▸ LMNA P02545 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9595859 0.89 MMP2 (0.45) MMP2ANPEPCA12CA1CA2
SCHEMBL14951725 0.89 MMP2 (0.45) MMP2ANPEPCA12CA1CA2
SCHEMBL9595866 0.89 MMP2 (0.45) MMP2ANPEPCA12CA1CA2
SCHEMBL7805520 0.86 MMP2 (0.48) MMP2ANPEPCA12CA1CA2
SCHEMBL9635513 0.84 GBA2 (0.37) MMP2ANPEPKMT2AALDH1A1LMNA
SCHEMBL3476452 0.83 MMP2 (0.53) MMP2ANPEPCA12CA1CA2
SCHEMBL5058842 0.83 MMP2 (0.48) MMP2ANPEPALDH1A1CYP3A4NR1H2
SCHEMBL7805563 0.83 MMP2 (0.48) MMP2ANPEPALDH1A1CYP3A4NR1H2
SCHEMBL489252 0.83 MMP2 (0.48) MMP2ANPEPALDH1A1CYP3A4NR1H2
SCHEMBL1154972 0.83 MMP2 (0.48) MMP2ANPEPALDH1A1CYP3A4NR1H2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3833672-B1 TRICYCLIC INHIBITORS OF HEPATITIS B VIRUS OSPEDALE SAN RAFFAELE SRL (IT) 2024-09-18 — — EP disclosed
US-20230076319-A1 INHIBITORS OF HEPATITIS B VIRUS ANTIOS THERAPEUTICS INC (US) 2023-03-09 — — US disclosed
US-11504382-B2 Tricyclic inhibitors of Hepatitis B virus Antios Therapeutics, Inc. (US) 2022-11-22 — — US disclosed
US-20220110943-A1 TRICYCLIC INHIBITORS OF HEPATITIS B VIRUS OSPEDALE SAN RAFFAELE S.R.L. (IT) 2022-04-14 — — US disclosed
WO-2020030781-A1 TRICYCLIC INHIBITORS OF HEPATITIS B VIRUS OSPEDALE SAN RAFFAELE S.R.L. (IT) 2020-02-13 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11504382-B2 Tricyclic inhibitors of Hepatitis B virus HAVCR2, NR1H4, HCCS MMP2 1211/4885ANPEP 1014/4885CA12 2556/4885
US-20220110943-A1 TRICYCLIC INHIBITORS OF HEPATITIS B VIRUS HAVCR2, NR1H4, HCCS MMP2 1211/4885ANPEP 1014/4885CA12 2556/4885
US-20230076319-A1 INHIBITORS OF HEPATITIS B VIRUS HAVCR2, HDGF, SLC10A1 MMP2 710/4885ANPEP 853/4885CA12 2128/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.