Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | HASPIN | Q8TF76 | 7/20 | 0.36 |
| ▸ | KIT | P10721 | 5/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.36 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | CDK7 | P50613 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3476458 | 0.97 | MAPK13 (0.37) | MAPK13MAPK12MAPK11MAPK14HASPIN | |
| SCHEMBL3475363 | 0.90 | CSNK1E (0.36) | MAPK13MAPK12MAPK11MAPK14HASPIN | |
| SCHEMBL3475362 | 0.87 | CSNK1E (0.36) | MAPK13MAPK12MAPK11MAPK14HASPIN | |
| SCHEMBL3109345 | 0.81 | CSNK1E (0.51) | MAPK13MAPK12MAPK11MAPK14KIT | |
| SCHEMBL3478546 | 0.77 | PTGDR2 (0.39) | MAPK13MAPK12MAPK11MAPK14HASPIN | |
| SCHEMBL3477121 | 0.77 | CSNK1E (0.50) | MAPK13MAPK12MAPK11MAPK14KIT | |
| SCHEMBL3476211 | 0.71 | CSNK1E (0.49) | MAPK13MAPK12MAPK11MAPK14CSNK1E | |
| SCHEMBL3476214 | 0.71 | CSNK1E (0.49) | MAPK13MAPK12MAPK11MAPK14CSNK1E | |
| SCHEMBL3116829 | 0.70 | CSNK1E (0.53) | PIM1CSNK1ECSNK1D | |
| SCHEMBL3106629 | 0.69 | CSNK1E (0.48) | MAPK13MAPK12MAPK11MAPK14CSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010130934-A2 | 2-CYCLOAMINO-5-(PYRIDIN-4-YL)IMIDAZO[2,1-B][1,3,4]THIADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-11-18 | — | — | WO | disclosed |