Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 4/20 | 0.50 |
| ▸ | KIT | P10721 | 3/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.35 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3477530 | 0.89 | CSNK1E (0.52) | CSNK1EMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL13072854 | 0.86 | CSNK1E (0.66) | CSNK1EKITMAPK14MAPK13MAPK12 | |
| SCHEMBL3477533 | 0.85 | CSNK1E (0.52) | CSNK1EMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL3111121 | 0.82 | CSNK1E (0.75) | CSNK1EKITMAPK14MAPK13MAPK12 | |
| SCHEMBL3111132 | 0.82 | CSNK1E (0.75) | CSNK1EKITMAPK14MAPK13MAPK12 | |
| SCHEMBL3478546 | 0.82 | PTGDR2 (0.39) | KITMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL3476458 | 0.80 | MAPK13 (0.37) | CSNK1EKITMAPK14MAPK13MAPK12 | |
| SCHEMBL3476459 | 0.77 | MAPK13 (0.39) | CSNK1EKITMAPK14MAPK13MAPK12 | |
| SCHEMBL3113102 | 0.74 | CSNK1E (0.60) | CSNK1EKITMAPK14MAPK13MAPK12 | |
| SCHEMBL3113093 | 0.74 | CSNK1E (0.60) | CSNK1EKITMAPK14MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010130934-A2 | 2-CYCLOAMINO-5-(PYRIDIN-4-YL)IMIDAZO[2,1-B][1,3,4]THIADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-11-18 | — | — | WO | disclosed |