Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 2/20 | 0.36 |
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.35 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3475363 | 0.97 | CSNK1E (0.36) | CSNK1EHASPINROCK2ROCK1CDC42BPA | |
| SCHEMBL3476458 | 0.90 | MAPK13 (0.37) | CSNK1EHASPINROCK2ROCK1CDC42BPA | |
| SCHEMBL3476459 | 0.87 | MAPK13 (0.39) | CSNK1EHASPINMAPK13MAPK12MAPK11 | |
| SCHEMBL3116829 | 0.83 | CSNK1E (0.53) | CSNK1EALDH1A1CYP3A4HSD17B10HPGD | |
| SCHEMBL3478506 | 0.80 | MAPK14 (0.39) | MAPK13MAPK12MAPK11MAPK14ADORA2A | |
| SCHEMBL3477530 | 0.79 | CSNK1E (0.52) | CSNK1EROCK2ROCK1MAPK13MAPK12 | |
| SCHEMBL3477533 | 0.76 | CSNK1E (0.52) | CSNK1EROCK2ROCK1MAPK13MAPK12 | |
| SCHEMBL3113529 | 0.75 | CSNK1E (0.46) | CSNK1EHASPINMAPK13MAPK12MAPK11 | |
| SCHEMBL3104980 | 0.74 | CSNK1E (0.51) | CSNK1EALDH1A1CYP3A4HSD17B10CYP1A2 | |
| SCHEMBL17976971 | 0.74 | CSNK1E (0.51) | CSNK1EROCK2ROCK1CDC42BPACDC42BPB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010130934-A2 | 2-CYCLOAMINO-5-(PYRIDIN-4-YL)IMIDAZO[2,1-B][1,3,4]THIADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-11-18 | — | — | WO | disclosed |