Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.49 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.49 |
| ▸ | PTPRC | P08575 | 1/20 | 0.56 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.54 |
| ▸ | ALPI | P09923 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | XIAP | P98170 | 1/20 | 0.54 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.54 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoric Acid SCHEMBL27545043 | 1.00 | PTPRC (0.56) | PTPRCSLC7A5PTPN1PTGS1ALPI | |
| SCHEMBL273663 | 0.98 | PTPRC (0.57) | PTPRCSLC7A5PTPN1PTGS1ALPI | |
| SCHEMBL4066744 | 0.98 | PTPRC (0.57) | PTPRCSLC7A5PTPN1PTGS1ALPI | |
| SCHEMBL3626587 | 0.98 | PTPRC (0.57) | PTPRCSLC7A5PTPN1PTGS1ALPI | |
| SCHEMBL1152 | 0.98 | PTPRC (0.57) | PTPRCSLC7A5PTPN1PTGS1ALPI | |
| SCHEMBL29567635 | 0.97 | PTPRC (0.56) | PTPRCSLC7A5PTPN1PTGS1ALPI | |
| SCHEMBL27947556 | 0.97 | PTPRC (0.56) | PTPRCSLC7A5PTPN1PTGS1ALPI | |
| SCHEMBL19615883 | 0.97 | PTPRC (0.56) | PTPRCSLC7A5PTPN1PTGS1ALPI | |
| SCHEMBL29613927 | 0.97 | PTPRC (0.56) | PTPRCSLC7A5PTPN1PTGS1ALPI | |
| Phosphine SCHEMBL28192584 | 0.97 | PTPRC (0.56) | PTPRCSLC7A5PTPN1PTGS1ALPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7769575-B2 | Three dimensional coordinates of HPTPbeta | Warner Chilcott, LLC (US) | 2010-08-03 | — | — | US | disclosed |
| US-20100030487-A1 | THREE DIMENSIONAL COORDINATES OF HPTPbeta | Aerpio Pharmaceuticals, Inc. | 2010-02-04 | — | — | US | disclosed |
| US-7507568-B2 | Three dimensional coordinates of HPTPbeta | THE PROCTOR & GAMBLE COMPANY (US) | 2009-03-24 | — | — | US | disclosed |
| CN-1812782-A | Pyrazolidinedione derivatives and their use as platelet aggregation inhibitors | ACTELION PHARMACEUTICALS LTD (CH) | 2006-08-02 | — | — | CN | disclosed |
| US-20060014932-A1 | Purified and isolated protein zero related (PZR) and therapeutic and screening methods using same | VANDERBILT UNIVERSITY | 2006-01-19 | — | — | US | disclosed |
| US-6939952-B2 | Purified and isolated protein zero related (PZR) polypeptide | VANDERBILT UNIVERSITY (US) | 2005-09-06 | — | — | US | disclosed |
| US-20040077065-A1 | Three dimensional coordinates of HPTPbeta | THE PROCTER & GAMBLE COMPANY | 2004-04-22 | — | — | US | disclosed |
| US-20030171565-A1 | Modulating cell signaling, detecting tyrosine kinase or tyrosine phosphatase biological activity | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-09-11 | — | — | US | disclosed |
| US-6355786-B1 | A NUCLEIC ACID ENCODING A TRANSMEMBRANE PROTEIN THAT BINDS TYROSINE PHOSPHATASE-2; DIAGNOSIS AND THERAPY FOR PROLIFERATIVE AND DIFFERENTIATION DISORDERS; THERAPY FOR TYPE 1B CHARCOT-MARIE TOOTH DISORDER | VANDERBILT UNIVERSITY | 2002-03-12 | — | — | US | disclosed |