Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.36 |
| ▸ | CTSA | P10619 | 3/20 | 0.35 |
| ▸ | FBP1 | P09467 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537370 | 0.85 | PDE4D (0.40) | PDE4DMAPTTHRBHCRTR1HCRTR2 | |
| SCHEMBL4336293 | 0.85 | PDE4D (0.41) | PDE4DMAPTTHRBHCRTR1HCRTR2 | |
| SCHEMBL4323960 | 0.84 | PDE4B (0.41) | PDE4DMAPTTHRBPDE4BHTR1A | |
| SCHEMBL3791661 | 0.83 | PDE4D (0.44) | PDE4DMAPTTHRBHCRTR1HCRTR2 | |
| SCHEMBL4530661 | 0.83 | MAPT (0.38) | PDE4DMAPTTHRBHCRTR1HCRTR2 | |
| SCHEMBL3467841 | 0.82 | SLC6A9 (0.39) | PDE4DMAPTTHRBHCRTR1HCRTR2 | |
| SCHEMBL3465778 | 0.82 | MAPT (0.40) | PDE4DMAPTTHRBHCRTR1HCRTR2 | |
| SCHEMBL3795483 | 0.81 | PDE4B (0.39) | PDE4DMAPTTHRBPDE4B | |
| SCHEMBL3791157 | 0.81 | PDE4D (0.45) | PDE4DHCRTR1HCRTR2CTSAFBP1 | |
| SCHEMBL7904591 | 0.80 | PDE4D (0.51) | PDE4DMAPTTHRBHCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222639-A1 | BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS | Decode Genetics EHF (IS) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009067621-A1 | BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |