Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 3/20 | 0.52 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.36 |
| ▸ | GCGR | P47871 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NMT1 | P30419 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3477530 | 0.96 | CSNK1E (0.52) | CSNK1EGRM2MAPK1MEN1KMT2A | |
| SCHEMBL13072854 | 0.88 | CSNK1E (0.66) | CSNK1EMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL3477121 | 0.85 | CSNK1E (0.50) | CSNK1EMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL3475363 | 0.79 | CSNK1E (0.36) | CSNK1EMAPK1MAPK14MAPK13MAPK12 | |
| SCHEMBL3478506 | 0.78 | MAPK14 (0.39) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL3475362 | 0.76 | CSNK1E (0.36) | CSNK1EMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL3476211 | 0.74 | CSNK1E (0.49) | CSNK1EMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL3476214 | 0.74 | CSNK1E (0.49) | CSNK1EMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL1744710 | 0.73 | CSNK1E (0.66) | CSNK1EMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL1743950 | 0.70 | CSNK1E (0.66) | CSNK1EACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010130934-A2 | 2-CYCLOAMINO-5-(PYRIDIN-4-YL)IMIDAZO[2,1-B][1,3,4]THIADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-11-18 | — | — | WO | disclosed |