Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.46 |
| ▸ | LMNA | P02545 | 6/20 | 0.46 |
| ▸ | GAA | P10253 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | APAF1 | O14727 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 3/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 3/20 | 0.46 |
| ▸ | NSD2 | O96028 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 2/20 | 0.46 |
| ▸ | SAE1 | Q9UBE0 | 2/20 | 0.46 |
| ▸ | UBA2 | Q9UBT2 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3476321 | 0.90 | MAPT (0.48) | MAPTLMNAGAAKMT2AAPAF1 | |
| SCHEMBL3476543 | 0.88 | MAPT (0.48) | MAPTLMNAGAAKMT2AAPAF1 | |
| SCHEMBL3477758 | 0.86 | MAPT (0.47) | MAPTLMNAGAAKMT2AAPAF1 | |
| SCHEMBL3476026 | 0.85 | MAPT (0.64) | MAPTLMNAGAAKMT2AAPAF1 | |
| SCHEMBL3476863 | 0.85 | KMT2A (0.46) | MAPTLMNAGAAKMT2AAPAF1 | |
| SCHEMBL3477427 | 0.82 | RAF1 (0.49) | MAPTGAAAPAF1SENP8SENP7 | |
| SCHEMBL3476638 | 0.82 | GAA (0.45) | MAPTLMNAGAAKMT2AAPAF1 | |
| SCHEMBL2789360 | 0.79 | APAF1 (0.52) | MAPTLMNAGAAKMT2AAPAF1 | |
| SCHEMBL3477429 | 0.78 | APAF1 (0.43) | MAPTLMNAGAAKMT2AAPAF1 | |
| SCHEMBL3475711 | 0.78 | GAA (0.44) | MAPTLMNAGAAKMT2AAPAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010130900-A2 | TRIAMINOPYRIMIDINE DERIVATIVES AS CDC25 PHOSPHATASE INHIBITORS | IPSEN PHARMA S.A.S. (FR) | 2010-11-18 | — | — | WO | claimed |
| WO-2010130900-A2 | TRIAMINOPYRIMIDINE DERIVATIVES AS CDC25 PHOSPHATASE INHIBITORS | IPSEN PHARMA S.A.S. (FR) | 2010-11-18 | — | — | WO | disclosed |