Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 13/20 | 0.49 |
| ▸ | BRAF | P15056 | 13/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | APAF1 | O14727 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.43 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3476638 | 0.91 | GAA (0.45) | RAF1BRAFPOLBAPAF1GAA | |
| SCHEMBL2788424 | 0.85 | RAF1 (0.39) | RAF1BRAFAPAF1GAAMAPT | |
| SCHEMBL2789360 | 0.84 | APAF1 (0.52) | ALDH1A1POLBAPAF1GAAMAPT | |
| SCHEMBL2770822 | 0.83 | THRB (0.43) | RAF1BRAFALDH1A1POLBGAA | |
| SCHEMBL3477339 | 0.82 | MAPT (0.46) | ALDH1A1POLBAPAF1GAAMAPT | |
| SCHEMBL3477429 | 0.82 | APAF1 (0.43) | ALDH1A1POLBAPAF1GAAMAPT | |
| SCHEMBL3475711 | 0.80 | GAA (0.44) | ALDH1A1POLBAPAF1GAAMAPT | |
| SCHEMBL3476321 | 0.79 | MAPT (0.48) | ALDH1A1POLBAPAF1GAAMAPT | |
| SCHEMBL3476543 | 0.79 | MAPT (0.48) | ALDH1A1POLBAPAF1GAAMAPT | |
| SCHEMBL3476026 | 0.79 | MAPT (0.64) | ALDH1A1POLBAPAF1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010130900-A2 | TRIAMINOPYRIMIDINE DERIVATIVES AS CDC25 PHOSPHATASE INHIBITORS | IPSEN PHARMA S.A.S. (FR) | 2010-11-18 | — | — | WO | claimed |
| WO-2010130900-A2 | TRIAMINOPYRIMIDINE DERIVATIVES AS CDC25 PHOSPHATASE INHIBITORS | IPSEN PHARMA S.A.S. (FR) | 2010-11-18 | — | — | WO | disclosed |