Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.46 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.46 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.42 |
| ▸ | CDC25B | P30305 | 1/20 | 0.42 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.42 |
| ▸ | CCR9 | P51686 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12458001 | 0.84 | TSHR (0.59) | TSHRCYP1A2CYP2C19L3MBTL1HSD17B10 | |
| SCHEMBL6306400 | 0.84 | TSHR (0.59) | TSHRCYP1A2CYP2C19L3MBTL1HSD17B10 | |
| SCHEMBL20599552 | 0.82 | MAPT (0.47) | TSHRHSD17B10ALDH1A1MAPTCA1 | |
| SCHEMBL11739500 | 0.81 | ALDH1A1 (0.57) | TSHRCYP1A2CYP2C19L3MBTL1HSD17B10 | |
| SCHEMBL19384283 | 0.78 | TSHR (0.51) | TSHRCYP1A2CYP2C19L3MBTL1HSD17B10 | |
| SCHEMBL8549717 | 0.77 | PKM (0.43) | CYP1A2CYP2C19L3MBTL1HSD17B10ALDH1A1 | |
| SCHEMBL8550619 | 0.76 | TSHR (0.49) | TSHRCYP1A2CYP2C19L3MBTL1HSD17B10 | |
| SCHEMBL31409354 | 0.76 | TSHR (0.47) | TSHRCYP1A2CYP2C19L3MBTL1HSD17B10 | |
| SCHEMBL4159419 | 0.76 | TSHR (0.47) | TSHRCYP1A2CYP2C19L3MBTL1HSD17B10 | |
| SCHEMBL11006678 | 0.74 | KDM4E (0.58) | TSHRCYP1A2CYP2C19HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010131030-A1 | PYRIDYLUREA DERIVATIVES AND THEIR THERAPEUTIC USE | PULMAGEN THERAPEUTICS (INFLAMMATION) LIMITED (GB) | 2010-11-18 | — | — | WO | disclosed |
| EP-0714393-B1 | THIAZOLES AS ANTIVIRAL | PFIZER (US) | 1998-09-23 | — | — | EP | disclosed |
| US-5789408-A | Antiviral thiazoles | PFIZER INC. (US) | 1998-08-04 | — | — | US | disclosed |
| EP-0714393-A1 | THIAZOLES AS ANTIVIRAL | PFIZER INC. (US) | 1996-06-05 | — | — | EP | disclosed |
| WO-1995005378-A1 | ANTIVIRAL THIAZOLES | PFIZER INC. (US) | 1995-02-23 | — | — | WO | disclosed |