Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.42 |
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15048649 | 0.91 | PTGS2 (0.45) | KCNH2JAK2PTK2CYP11B1CYP11B2 | |
| SCHEMBL2520439 | 0.84 | MEN1 (0.49) | — | |
| SCHEMBL520169 | 0.82 | JAK2 (0.59) | JAK2PTK2 | |
| SCHEMBL3478587 | 0.78 | JAK2 (0.44) | JAK2PTK2CYP11B1CYP11B2 | |
| SCHEMBL15048630 | 0.76 | JAK2 (0.48) | JAK2PTK2 | |
| SCHEMBL519674 | 0.74 | KCNH2 (0.55) | KCNH2JAK2PTK2NR1H2 | |
| SCHEMBL520633 | 0.73 | JAK2 (0.56) | JAK2PTK2PTGS2PTGS1 | |
| SCHEMBL15650181 | 0.71 | PTGS2 (0.58) | CYP11B1CYP11B2PTGS2PTGS1 | |
| SCHEMBL19221995 | 0.71 | PTGS2 (0.43) | PTGS2PTGS1 | |
| SCHEMBL521283 | 0.71 | JAK2 (0.71) | JAK2PTK2CYP11B1CYP11B2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-B1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON INC (US) | 2015-03-04 | — | — | EP | disclosed |
| US-8471005-B2 | Pyrrolotriazines as ALK and JAK2 inhibitors | CEPHALON, INC. (US) | 2013-06-25 | — | — | US | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |