Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3478583 | 0.84 | KCNH2 (0.42) | — | |
| SCHEMBL520782 | 0.84 | INSR (0.54) | MEN1KMT2ARAB9AMAPK1ALDH1A1 | |
| SCHEMBL15048649 | 0.78 | PTGS2 (0.45) | — | |
| SCHEMBL520063 | 0.78 | POLB (0.49) | MEN1KMT2ARAB9AMAPK1ALDH1A1 | |
| SCHEMBL521613 | 0.76 | JAK2 (0.53) | MEN1KMT2AMAPK1ALDH1A1LMNA | |
| SCHEMBL3478587 | 0.71 | JAK2 (0.44) | — | |
| SCHEMBL520683 | 0.70 | INSR (0.68) | KMT2AALDH1A1GAASMN1; SMN2KDM4E | |
| SCHEMBL15048630 | 0.69 | JAK2 (0.48) | POLBMAPT | |
| SCHEMBL521040 | 0.69 | ALDH1A1 (0.45) | MEN1KMT2AMAPK1ALDH1A1GAA | |
| SCHEMBL520169 | 0.68 | JAK2 (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |