Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | FGB | P02675 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | RARA | P10276 | 1/20 | 0.40 |
| ▸ | RARB | P10826 | 1/20 | 0.40 |
| ▸ | RARG | P13631 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13196487 | 0.80 | GAA (0.59) | MAPK1GAAKMT2AMEN1POLB | |
| SCHEMBL8273477 | 0.79 | GAA (0.57) | MAPK1GAAKMT2AMEN1POLB | |
| SCHEMBL3468468 | 0.77 | KMT2A (0.48) | MAPK1GAAKMT2AMEN1POLB | |
| SCHEMBL30459975 | 0.76 | PGR (0.51) | MAPK1KMT2AMEN1IP6K1LMNA | |
| SCHEMBL29041890 | 0.76 | PGR (0.51) | MAPK1KMT2AMEN1IP6K1LMNA | |
| SCHEMBL5335747 | 0.76 | GAA (0.62) | MAPK1GAAKMT2AMEN1POLB | |
| SCHEMBL12548325 | 0.76 | IP6K1 (0.57) | IP6K1LMNAALDH1A1 | |
| SCHEMBL13196473 | 0.76 | GAA (0.57) | MAPK1GAAKMT2AMEN1POLB | |
| SCHEMBL4904403 | 0.75 | IP6K1 (0.45) | MAPK1GAAKMT2AMEN1IP6K1 | |
| SCHEMBL8273542 | 0.74 | KMT2A (0.88) | MAPK1GAAKMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010077839-A1 | SUBSTITUTED OXINDOL CB2 AGONISTS FOR PAIN TREATMENT | WYETH LLC (FORMERLY KNOWN AS WYETH) (US) | 2010-07-08 | — | — | WO | disclosed |
| WO-2010077839-A1 | SUBSTITUTED OXINDOL CB2 AGONISTS FOR PAIN TREATMENT | WYETH LLC (FORMERLY KNOWN AS WYETH) (US) | 2010-07-08 | — | — | WO | disclosed |