Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.40 |
| ▸ | NPC1 | O15118 | 7/20 | 0.40 |
| ▸ | RAB9A | P51151 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | HTT | P42858 | 5/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | RAD52 | P43351 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | RGS12 | O14924 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 2/20 | 0.37 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18035808 | 0.98 | NPC1 (0.41) | SMN1; SMN2NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL16115237 | 0.94 | SMN1; SMN2 (0.46) | SMN1; SMN2NPC1RAB9AKDM4EMEN1 | |
| Acetic Acid SCHEMBL15210171 | 0.89 | NPC1 (0.35) | SMN1; SMN2NPC1RAB9AKDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL30330888 | 0.81 | SMN1; SMN2 (0.45) | SMN1; SMN2NPC1RAB9AKDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL9327469 | 0.81 | SMN1; SMN2 (0.45) | SMN1; SMN2NPC1RAB9AKDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL29251700 | 0.80 | SMN1; SMN2 (0.44) | SMN1; SMN2NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL329217 | 0.79 | NPC1 (0.46) | SMN1; SMN2NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL29561039 | 0.79 | NPC1 (0.46) | SMN1; SMN2NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL12558270 | 0.78 | NPC1 (0.45) | SMN1; SMN2NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL28139801 | 0.78 | NPC1 (0.45) | SMN1; SMN2NPC1RAB9AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2638123-B1 | WORKING MEDIUM FOR ABSORPTION HEAT PUMPS | EVONIK DEGUSSA GMBH (DE) | 2016-08-31 | — | — | EP | claimed |
| US-20130219949-A1 | WORKING MEDIUM FOR ABSORPTION HEAT PUMPS | EVONIK DEGUSSA GMBH (DE) | 2013-08-29 | — | — | US | claimed |
| US-20130219949-A1 | WORKING MEDIUM FOR ABSORPTION HEAT PUMPS | EVONIK DEGUSSA GMBH (DE) | 2013-08-29 | — | — | US | disclosed |
| CN-1830928-B | Process for the preparation of alkyl chlorides | EVONIK DEGUSSA GMBH | 2010-12-08 | — | — | CN | disclosed |
| US-7652180-B2 | Process for preparing alkyl chlorides | DEGUSSA AG (DE) | 2010-01-26 | — | — | US | disclosed |
| US-20060205987-A1 | Process for preparing alkyl chlorides | DEGUSSA AG (DE) | 2006-09-14 | — | — | US | disclosed |
| CN-1830928-A | Process for the preparation of alkyl chlorides | DEGUSSA (DE) | 2006-09-13 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060205987-A1 | Process for preparing alkyl chlorides | HACL2, ARL1, MGLL | ACHE 3436/4885SMN1; SMN2 4464/4885NPC1 3161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.