Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 4/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3479505 | 0.90 | MCHR1 (0.41) | MCHR1NOTUMNSD2ALOX5CHRM2 | |
| SCHEMBL13030986 | 0.86 | MCHR1 (0.48) | MCHR1CHRM2CHRM1OPRM1KCNH2 | |
| SCHEMBL13030985 | 0.80 | MCHR1 (0.47) | MCHR1NOTUMNSD2ALOX5DRD2 | |
| SCHEMBL13030992 | 0.77 | MCHR1 (0.41) | MCHR1CHRM2CHRM1OPRM1KCNH2 | |
| SCHEMBL3479525 | 0.75 | BACE1 (0.49) | MCHR1 | |
| SCHEMBL5305865 | 0.75 | BACE1 (0.41) | ALOX5ADAMTS5OPRM1METAP2 | |
| SCHEMBL4734282 | 0.75 | BACE1 (0.41) | ALOX5ADAMTS5OPRM1METAP2 | |
| Trifluoroacetic Acid SCHEMBL4254495 | 0.74 | BACE1 (0.47) | MCHR1 | |
| Trifluoroacetic Acid SCHEMBL3479431 | 0.74 | BACE1 (0.47) | MCHR1 | |
| SCHEMBL14248524 | 0.69 | ADAMTS5 (0.36) | ALOX5ADAMTS5DRD2DRD3METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298342-A1 | Spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's Disease | MERCK & CO., INC. (US) | 2010-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298342-A1 | Spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's Disease | BACE1, APP, PSEN1 | MCHR1 4417/4885NOTUM 487/4885NSD2 3703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.