Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3495487 | 0.69 | MEN1 (0.36) | MEN1NR1I2AHRKMT2ANTRK1 | |
| Hydrochloric Acid SCHEMBL1899672 | 0.69 | MEN1 (0.34) | MEN1NR1I2AHRKMT2ANTRK1 | |
| SCHEMBL26439497 | 0.69 | KMT2A (0.39) | MEN1NR1I2AHRKMT2ANTRK1 | |
| SCHEMBL17842624 | 0.69 | MEN1 (0.42) | MEN1NR1I2AHRKMT2ANTRK1 | |
| Hydrochloric Acid SCHEMBL1899675 | 0.69 | MEN1 (0.35) | MEN1NR1I2AHRKMT2ANTRK1 | |
| Hydrochloric Acid SCHEMBL17976520 | 0.69 | MEN1 (0.33) | MEN1NR1I2AHRKMT2ANTRK1 | |
| SCHEMBL17494570 | 0.68 | MEN1 (0.34) | MEN1NR1I2AHRKMT2ANTRK1 | |
| Hydrochloric Acid SCHEMBL17976528 | 0.67 | KDM4E (0.33) | MEN1NR1I2AHRKMT2AKDM4E | |
| SCHEMBL17527505 | 0.67 | KDM4E (0.34) | MEN1NR1I2AHRKMT2ANTRK1 | |
| SCHEMBL12382598 | 0.61 | MEN1 (0.35) | MEN1NR1I2AHRKMT2ANTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7829641-B2 | Process for the preparation of multimodal polyethylene resins | EQUISTAR CHEMICALS, LP (US) | 2010-11-09 | — | — | US | disclosed |
| US-20100016526-A1 | Process for the preparation of multimodal polyethylene resins | EQUISTAR CHEMICALS, LP | 2010-01-21 | — | — | US | disclosed |