Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7634800 | 0.88 | NTRK1 (0.33) | NTRK1 | |
| Hydrochloric Acid SCHEMBL1899675 | 0.77 | MEN1 (0.35) | MEN1NR1I2AHRKMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL7128456 | 0.73 | GPR3 (0.31) | NTRK1 | |
| Hydrochloric Acid SCHEMBL524858 | 0.72 | GPR3 (0.33) | — | |
| Methane SCHEMBL5348855 | 0.71 | GPR3 (0.32) | — | |
| Hydrochloric Acid SCHEMBL3495487 | 0.71 | MEN1 (0.36) | MEN1NR1I2AHRKMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL6244416 | 0.71 | KDM4E (0.37) | MEN1NR1I2AHRKMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL6230243 | 0.70 | — | — | |
| Hydrochloric Acid SCHEMBL6230015 | 0.70 | CHRNB2 (0.33) | — | |
| Cyclopentane SCHEMBL6557619 | 0.70 | BCHE (0.33) | BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7829641-B2 | Process for the preparation of multimodal polyethylene resins | EQUISTAR CHEMICALS, LP (US) | 2010-11-09 | — | — | US | claimed |
| US-20100016526-A1 | Process for the preparation of multimodal polyethylene resins | EQUISTAR CHEMICALS, LP | 2010-01-21 | — | — | US | claimed |
| EP-2321369-A1 | POLYETHYLENE THICK FILM AND PROCESS FOR PREPARING POLYETHYLENE | Equistar Chemicals, LP (US) | 2011-05-18 | — | — | EP | disclosed |
| US-7829641-B2 | Process for the preparation of multimodal polyethylene resins | EQUISTAR CHEMICALS, LP (US) | 2010-11-09 | — | — | US | disclosed |
| US-7816478-B2 | Polyethylene thick film and process for preparing polyethylene | EQUISTAR CHEMICALS, LP (US) | 2010-10-19 | — | — | US | disclosed |
| WO-2010027396-A1 | POLYETHYLENE THICK FILM AND PROCESS FOR PREPARING POLYETHYLENE | EQUISTAR CHEMICALS, LP (US) | 2010-03-11 | — | — | WO | disclosed |
| US-20100055432-A1 | thickness of 50 to 200 microns; Ethylene-Octene copolymer; bimodal molecular weight distribution; high impact strength; high modulus; two slurry zones with bridged and non-bridged zirconium complex catalysts; dialkylsilylene-bridged and unbridged cyclopentadienyl(indeno[2,1-b]indolyl)zirconium complex | EQUISTAR CHEMICALS, LP | 2010-03-04 | — | — | US | disclosed |
| US-20100016526-A1 | Process for the preparation of multimodal polyethylene resins | EQUISTAR CHEMICALS, LP | 2010-01-21 | — | — | US | disclosed |