Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phosphocholine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 6/20 | 0.68 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.68 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.68 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.68 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.68 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.68 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.68 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | HTR1A | P08908 | 2/20 | 0.68 |
| ▸ | PGR | P06401 | 1/20 | 0.68 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.68 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.68 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.68 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.68 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.68 |
| ▸ | GALR3 | O60755 | 2/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetylcholine SCHEMBL28462551 | 0.87 | CHRM5 (0.80) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Acetylcholine SCHEMBL1258635 | 0.85 | CHRM5 (0.73) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Phosphocholine SCHEMBL18192302 | 0.84 | LMNA (0.55) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Acetylcholine SCHEMBL30066972 | 0.84 | CHRM1 (0.95) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Phosphocholine SCHEMBL9447039 | 0.84 | LMNA (0.55) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL19734900 | 0.84 | SMN1; SMN2 (0.60) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Phosphocholine SCHEMBL3485575 | 0.84 | CHRM5 (0.70) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Acetylcholine SCHEMBL27531690 | 0.83 | CHRM1 (0.83) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Phosphocholine SCHEMBL10717808 | 0.82 | LMNA (0.53) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Phosphocholine SCHEMBL9447028 | 0.82 | LMNA (0.53) | CHRM5CHRM1CHRM3CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9228175-B2 | Genes encoding a novel type of lysophophatidylcholine acyltransferases and their use to increase triacylglycerol production and/or modify fatty acid composition | NATIONAL RESEARCH COUNSEL OF CANADA (CA) | 2016-01-05 | — | — | US | disclosed |
| US-20130152230-A1 | GENES ENCODING A NOVEL TYPE OF LYSOPHOPHATIDYLCHOLINE ACYLTRANSFERASES AND THEIR USE TO INCREASE TRIACYLGLYCEROL PRODUCTION AND/OR MODIFY FATTY ACID COMPOSITION | DOW AGROSCIENCES LLC (US) | 2013-06-13 | — | — | US | disclosed |
| US-8383886-B2 | Genes encoding a novel type of lysophophatidylcholine acyltransferases and their use to increase triacylglycerol production and/or modify fatty acid composition | NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 2013-02-26 | — | — | US | disclosed |
| US-20100016431-A1 | GENES ENCODING A NOVEL TYPE OF LYSOPHOPHATIDYLCHOLINE ACYLTRANSFERASES AND THEIR USE TO INCREASE TRIACYLGLYCEROL PRODUCTION AND/OR MODIFY FATTY ACID COMPOSITION | NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 2010-01-21 | — | — | US | disclosed |
| WO-2008076377-A2 | GENES ENCODING A NOVEL TYPE OF LYSOPHOPHATIDYLCHOLINE ACYLTRANSFERASES AND THEIR USE TO INCREASE TRIACYLGLYCEROL PRODUCTION AND/OR MODIFY FATTY ACID COMPOSITION | NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 2008-06-26 | — | — | WO | disclosed |