Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acetylcholine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 6/20 | 0.73 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.73 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.73 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.73 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.73 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.73 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.73 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.73 |
| ▸ | HTR1A | P08908 | 2/20 | 0.73 |
| ▸ | PGR | P06401 | 1/20 | 0.73 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.73 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.73 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.73 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.73 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.73 |
| ▸ | GALR3 | O60755 | 2/20 | 0.70 |
| ▸ | GAA | P10253 | 1/20 | 0.70 |
| ▸ | RAB9A | P51151 | 1/20 | 0.70 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetylcholine SCHEMBL27970924 | 0.92 | CHRM1 (0.79) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Acetylcholine SCHEMBL1258634 | 0.90 | CHRM1 (0.76) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Acetylcholine SCHEMBL28462551 | 0.90 | CHRM5 (0.80) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Acetylcholine SCHEMBL8513991 | 0.88 | CHRM1 (0.95) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Acetylcholine SCHEMBL27531690 | 0.86 | CHRM1 (0.83) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Acetylcholine SCHEMBL29113198 | 0.86 | CHRM1 (0.91) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Acetylcholine SCHEMBL2518957 | 0.85 | CHRM1 (1.00) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Acetylcholine SCHEMBL3216 | 0.85 | CHRM1 (1.00) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Phosphocholine SCHEMBL3485572 | 0.85 | CHRM5 (0.68) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Acetylcholine SCHEMBL28462553 | 0.84 | CHRM1 (0.79) | CHRM5CHRM1CHRM3CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4937369-A | Analogues of phosphatidylcholine or phosphatidyl ethanol amines | BIOCOMPATIBLE, LTD. (GB) | 1990-06-26 | — | — | US | claimed |
| EP-0157469-A1 | Phosphoric acid esters, their preparation and their use for the preparation of biocompatible surfaces | BIOCOMPATIBLES LTD. (GB) | 1985-10-09 | — | — | EP | claimed |
| US-20110040248-A1 | METHODS AND IMPLANTABLE DEVICES FOR TREATING SUPRAVENTRICULAR ARRHYTHMIAS | CLOSED LOOP THERAPIES BV (NL) | 2011-02-17 | — | — | US | disclosed |
| US-7781402-B2 | Methods and implantable devices for treating supraventricular arrhythmias | CLOSED LOOP THERAPIES LTD. (IL) | 2010-08-24 | — | — | US | disclosed |
| EP-1809374-A4 | METHODS AND IMPLANTABLE DEVICES FOR TREATING SUPRAVENTRICULAR ARRHYTHMIAS | CLOSED LOOP THERAPIES LTD (IL) | 2008-09-10 | — | — | EP | disclosed |
| EP-1809374-A1 | METHODS AND IMPLANTABLE DEVICES FOR TREATING SUPRAVENTRICULAR ARRHYTHMIAS | Closed Loop Therapies Ltd. (IL) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006040765-A1 | METHODS AND IMPLANTABLE DEVICES FOR TREATING SUPRAVENTRICULAR ARRHYTHMIAS | CLOSED LOOP THERAPIES LTD. (IL) | 2006-04-20 | — | — | WO | disclosed |
| US-20060079941-A1 | Methods and implantable devices for treating supraventricular arrhythmias | CLOSED LOOP THERAPIES LTD. (IL) | 2006-04-13 | — | — | US | disclosed |
| US-5380904-A | Process for rendering a surface biocompatible, and articles containing the same | BIOCOMPATIBLES LTD. (GB) | 1995-01-10 | — | — | US | disclosed |
| US-5229162-A | Article having biocompatible surface | BIOCOMPATIBLES LTD. (GB) | 1993-07-20 | — | — | US | disclosed |
| EP-0275293-B1 | POLYESTERS | BIOCOMPATIBLES LTD. (GB) | 1992-10-21 | — | — | EP | disclosed |
| US-5091551-A | Trialkyl-O-(W-aminoalkyl)-phosphatidylalkylammonium salts useful for the manufacture of biocompatible surfaces | BIOCOMPATIBLES LTD. (GB) | 1992-02-25 | — | — | US | disclosed |
| US-4937369-A | Analogues of phosphatidylcholine or phosphatidyl ethanol amines | BIOCOMPATIBLE, LTD. (GB) | 1990-06-26 | — | — | US | disclosed |
| EP-0157469-B1 | PHOSPHORIC ACID ESTERS, THEIR PREPARATION AND THEIR USE FOR THE PREPARATION OF BIOCOMPATIBLE SURFACES | BIOCOMPATIBLES LTD. (GB) | 1989-05-31 | — | — | EP | disclosed |
| US-4792599-A | Biocompatible polyesters | BIOCOMPATIBLES LTD. (GB) | 1988-12-20 | — | — | US | disclosed |
| EP-0275293-A1 | POLYESTERS. | BIOCOMPATIBLES LTD (GB) | 1988-07-27 | — | — | EP | disclosed |
| WO-1988000956-A1 | POLYESTERS | BIOCOMPATIBLES LIMITED (GB) | 1988-02-11 | — | — | WO | disclosed |
| US-4721800-A | Biocompatible surfaces | BIOCOMPATIBLES LTD. (GB) | 1988-01-26 | — | — | US | disclosed |
| EP-0157469-A1 | Phosphoric acid esters, their preparation and their use for the preparation of biocompatible surfaces | BIOCOMPATIBLES LTD. (GB) | 1985-10-09 | — | — | EP | disclosed |
| WO-1985003295-A1 | PHOSPHORIC ACID ESTERS, THEIR PREPARATION AND THEIR USE FOR THE PREPARATION OF BIOCOMPATIBLE SURFACES | BIOCOMPATIBLES LTD. (GB) | 1985-08-01 | — | — | WO | disclosed |