Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR3 | P46089 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.56 |
| ▸ | ACHE | P22303 | 5/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | GLA | P06280 | 2/20 | 0.56 |
| ▸ | CASP1 | P29466 | 2/20 | 0.56 |
| ▸ | CASP7 | P55210 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | NQO2 | P16083 | 1/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | DRD1 | P21728 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22776964 | 0.77 | GPR3 (0.54) | GPR3KDM4EHSD17B10ALDH1A1ACHE | |
| SCHEMBL11732580 | 0.77 | GPR3 (0.54) | GPR3KDM4EHSD17B10ALDH1A1ACHE | |
| Benzonaphthyridine SCHEMBL51197 | 0.76 | GPR3 (1.00) | GPR3KDM4EHSD17B10ALDH1A1ACHE | |
| Benzonaphthyridine SCHEMBL29600756 | 0.76 | GPR3 (1.00) | GPR3KDM4EHSD17B10ALDH1A1ACHE | |
| Benzonaphthyridine SCHEMBL30897319 | 0.76 | GPR3 (1.00) | GPR3KDM4EHSD17B10ALDH1A1ACHE | |
| SCHEMBL221530 | 0.73 | KDM4E (1.00) | GPR3KDM4EHSD17B10ALDH1A1ACHE | |
| SCHEMBL31416835 | 0.73 | KDM4E (1.00) | GPR3KDM4EHSD17B10ALDH1A1ACHE | |
| SCHEMBL9496321 | 0.73 | LCK (0.77) | GPR3KDM4EHSD17B10ALDH1A1ACHE | |
| SCHEMBL20301264 | 0.73 | KDM4E (0.48) | GPR3KDM4EHSD17B10ALDH1A1ACHE | |
| Aminacrine SCHEMBL29354393 | 0.72 | HSD17B10 (1.00) | KDM4EHSD17B10ALDH1A1ACHEHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257536-A2 | CYCLIC DIARYL ETHER AS ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009102893-A2 | CYCLIC DIARYL ETHER COMPOUNDS AS ANTAGONISTS OF PROSTAGLANDIN D2 receptors | AMIRA PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |