SCHEMBL3486159

SCHEMBL3486159

O=P(O)(O)On1nc2ccc(Cl)cc2n1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F7 P08709 1/20 0.35
F3 P13726 1/20 0.35
DYRK1A Q13627 1/20 0.35
MAPT P10636 3/20 0.35
KDM4E B2RXH2 2/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
ATM Q13315 1/20 0.35
CA1 P00915 1/20 0.35
CA14 Q9ULX7 1/20 0.35
RXFP1 Q9HBX9 1/20 0.32
MEN1 O00255 1/20 0.32
USP2 O75604 1/20 0.32
ALDH1A1 P00352 1/20 0.32
KMT2A Q03164 1/20 0.32
HSD17B10 Q99714 1/20 0.32
GGPS1 O95749 1/20 0.32
PIK3CG P48736 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
ADORA2A P29274 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3486091 0.78 SRC (0.39) MAPTKDM4ENPC1RAB9AUSP2
Phosphoric Acid SCHEMBL3486158 0.77 KDM4E (0.41) F7F3DYRK1AMAPTKDM4E
SCHEMBL10912104 0.70 KDM4E (0.47) F7F3DYRK1AMAPTKDM4E
SCHEMBL3485169 0.70 KMT2A (0.47) NPC1RAB9AMEN1ALDH1A1KMT2A
SCHEMBL25232020 0.68 F7 (0.46) F7F3DYRK1AMAPTKDM4E
SCHEMBL12126371 0.66 F7 (0.45) F7F3DYRK1AMAPTKDM4E
SCHEMBL29018345 0.66 KCNMA1 (0.48) MAPTKDM4ENPC1RAB9ACA1
SCHEMBL27522759 0.65 F7 (0.43) F7F3DYRK1AMAPTKDM4E
SCHEMBL205114 0.63 CNR1 (0.39) DYRK1AMAPTKDM4ENPC1RAB9A
SCHEMBL27627295 0.63 MAPT (0.53) MAPTKDM4ENPC1RAB9AATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100029008-A1 POLYMERASE-INDEPENDENT ANALYSIS OF THE SEQUENCE OF POLYNUCLEOTIDES FEBIT BIOTECH GMBH (DE) 2010-02-04 US claimed
EP-1828217-A2 POLYMERASE-INDEPENDENT ANALYSIS OF THE SEQUENCE OF POLYNUCLEOTIDES Febit Biotech GmbH (DE) 2007-09-05 EP claimed
WO-2006063717-A2 POLYMERASE-INDEPENDENT ANALYSIS OF THE SEQUENCE OF POLYNUCLEOTIDES FEBIT BIOTECH GMBH (DE) 2006-06-22 WO claimed
US-20100029008-A1 POLYMERASE-INDEPENDENT ANALYSIS OF THE SEQUENCE OF POLYNUCLEOTIDES FEBIT BIOTECH GMBH (DE) 2010-02-04 US disclosed
EP-1828217-A2 POLYMERASE-INDEPENDENT ANALYSIS OF THE SEQUENCE OF POLYNUCLEOTIDES Febit Biotech GmbH (DE) 2007-09-05 EP disclosed
WO-2006063717-A2 POLYMERASE-INDEPENDENT ANALYSIS OF THE SEQUENCE OF POLYNUCLEOTIDES FEBIT BIOTECH GMBH (DE) 2006-06-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100029008-A1 POLYMERASE-INDEPENDENT ANALYSIS OF THE SEQUENCE OF POLYNUCLEOTIDES POLB, POLM, POLN F7 3975/4885F3 3346/4885DYRK1A 3196/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.