Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.71 |
| ▸ | USP2 | O75604 | 1/20 | 0.71 |
| ▸ | PKM | P14618 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.68 |
| ▸ | MMP9 | P14780 | 2/20 | 0.67 |
| ▸ | MMP8 | P22894 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | IDO1 | P14902 | 1/20 | 0.62 |
| ▸ | TDO2 | P48775 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | GSK3B | P49841 | 1/20 | 0.58 |
| ▸ | MMP2 | P08253 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | CBX7 | O95931 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13274391 | 1.00 | ALDH1A1 (0.71) | ALDH1A1USP2PKMLMNAMAPT | |
| SCHEMBL29458128 | 1.00 | ALDH1A1 (0.71) | ALDH1A1USP2PKMLMNAMAPT | |
| SCHEMBL29458096 | 0.90 | ALDH1A1 (0.70) | ALDH1A1USP2PKMLMNAMAPT | |
| SCHEMBL28454292 | 0.90 | ALDH1A1 (0.70) | ALDH1A1USP2PKMLMNAMAPT | |
| SCHEMBL28459576 | 0.88 | ALDH1A1 (0.69) | ALDH1A1USP2PKMLMNAMAPT | |
| SCHEMBL29458123 | 0.88 | ALDH1A1 (0.65) | ALDH1A1USP2PKMLMNAMAPT | |
| SCHEMBL29458109 | 0.88 | ALDH1A1 (0.69) | ALDH1A1USP2PKMLMNAMAPT | |
| SCHEMBL29458120 | 0.88 | ALDH1A1 (0.69) | ALDH1A1USP2PKMLMNAMAPT | |
| SCHEMBL28609487 | 0.88 | ALDH1A1 (0.69) | ALDH1A1USP2PKMLMNAMAPT | |
| SCHEMBL15337338 | 0.86 | KDM4E (0.72) | ALDH1A1USP2PKMLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111518086-B | Oxoindole-naphthofuran derivatives, preparation method and application thereof, and pharmaceutical composition and preparation containing same | 广州医科大学 | 2021-08-06 | — | — | CN | claimed |
| CN-111518086-A | Oxoindole-naphthofuran derivatives, preparation method and application thereof, and pharmaceutical composition and preparation containing same | 广州医科大学 | 2020-08-11 | — | — | CN | claimed |
| CN-111518086-B | Oxoindole-naphthofuran derivatives, preparation method and application thereof, and pharmaceutical composition and preparation containing same | 广州医科大学 | 2021-08-06 | — | — | CN | disclosed |
| CN-111518086-A | Oxoindole-naphthofuran derivatives, preparation method and application thereof, and pharmaceutical composition and preparation containing same | 广州医科大学 | 2020-08-11 | — | — | CN | disclosed |
| US-9758481-B2 | Targeting of EWS-FLI1 as anti-tumor therapy | GEORGETOWN UNIVERSITY (US) | 2017-09-12 | — | — | US | disclosed |
| CN-104761600-B | Synthesis and uses of beta-1-imidazole-2,3,4,6-tetrahydroxy-D-glucopyranose bromide | 江苏师范大学 | 2017-04-26 | — | — | CN | disclosed |
| US-20150329488-A1 | TARGETING OF EWS-FLI1 AS ANTI-TUMOR THERAPY | GEORGETOWN UNIVERSITY | 2015-11-19 | — | — | US | disclosed |
| CN-104761600-A | Synthesis and uses of beta-1-imidazole-2,3,4,6-tetrahydroxy-D-glucopyranose bromide | UNIV JIANGSU NORMAL | 2015-07-08 | — | — | CN | disclosed |
| CN-104761601-A | Synthesis and uses of beta-1-imidazole-2,3,4,6-tetrasulfo-D-glucopyranose hydrosulfate | UNIV JIANGSU NORMAL | 2015-07-08 | — | — | CN | disclosed |
| US-9045415-B2 | Targeting of EWS-FLI1 as anti-tumor therapy | GEORGETOWN UNIVERSITY (US) | 2015-06-02 | — | — | US | disclosed |
| EP-2687206-A1 | Targeting of EWS-FLI1 as anti-tumor therapy | Georgetown University (US) | 2014-01-22 | — | — | EP | disclosed |
| US-8232310-B2 | Targeting of EWS-FLI1 as anti-tumor therapy | GEORGETOWN UNIVERSITY (US) | 2012-07-31 | — | — | US | disclosed |
| US-20120122910-A1 | METHOD OF TREATING CANCER USING A SURVIVIN INHIBITOR | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2012-05-17 | — | — | US | disclosed |
| US-20120122910-A1 | METHOD OF TREATING CANCER USING A SURVIVIN INHIBITOR | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2012-05-17 | — | — | US | disclosed |
| WO-2010083505-A1 | METHOD OF TREATING CANCER USING A SURVIVIN INHIBITOR | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-07-22 | — | — | WO | disclosed |
| US-20100167994-A1 | TARGETING OF EWS-FLI1 AS ANTI-TUMOR THERAPY | GEORGETOWN UNIVERSITY (US) | 2010-07-01 | — | — | US | disclosed |
| US-20100004179-A1 | TARGETING OF EWS-FLI1 AS ANTI-TUMOR THERAPY | GEORGETOWN UNIVERSITY | 2010-01-07 | — | — | US | disclosed |
| EP-2124910-A2 | TARGETING OF EWS-FLI1 AS ANTI-TUMOR THERAPY | Georgetown University (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008083326-A2 | TARGETING OF EWS-FLI1 AS ANTI-TUMOR THERAPY | GEORGETOWN UNIVERSITY (US) | 2008-07-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004179-A1 | TARGETING OF EWS-FLI1 AS ANTI-TUMOR THERAPY | EWSR1, FLI1, PELI1 | ALDH1A1 3435/4885USP2 867/4885PKM 4215/4885 |
| US-20120122910-A1 | METHOD OF TREATING CANCER USING A SURVIVIN INHIBITOR | BIRC5, CDC20, CCNB1 | ALDH1A1 1765/4885USP2 1616/4885PKM 3920/4885 |
| US-20150329488-A1 | TARGETING OF EWS-FLI1 AS ANTI-TUMOR THERAPY | EWSR1, FLI1, PELI1 | ALDH1A1 3435/4885USP2 867/4885PKM 4215/4885 |
| US-20100167994-A1 | TARGETING OF EWS-FLI1 AS ANTI-TUMOR THERAPY | EWSR1, FLI1, PELI1 | ALDH1A1 3435/4885USP2 867/4885PKM 4215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.